Magnetic resonance in medicine · 2025
Rapid free-breathing myocardial T1 mapping with free-running interleaved multi-slice acquisition and respiratory motion correction using self-navigated auto calibration.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Huang Hongzhang, Zhou Zijian, Lyu Zhenfeng, Miao Qinfang, Chen Genqiang, Hu Peng, Qi Haikun
Аннотация
PURPOSE: To develop a rapid 2D free-running myocardial T 1 $$ {T}_1 $$ mapping technique that is robust to through-plane respiratory motion.
METHODS: A free-running golden angle radial sequence consisting of T 1 $$ {T}_1 $$ encoding and self-navigated auto motion calibration (SNAC) was developed. The T 1 $$ {T}_1 $$ encoding adopted inversion recovery (IR) prepared interleaved multi-slice acquisition with optimized inter-slice gap to ensure a uniform excitation of the middle slice regardless of through-plane respiratory motion. The flip angles were alternated between the odd and even IR readouts to correct flip-angle errors. SNAC was designed to calibrate the through-plane motion with the respiratory self-navigation signal extracted from the free-running sequence, and integrate the multi-slice data into a through-plane motion-corrected 2D slice for T 1 $$ {T}_1 $$ mapping reconstruction. Numerical simulations were performed to optimize the key sequence parameters, followed by phantom and in-vivo imaging to validate the accuracy and repeatability.
RESULTS: Numerical simulations yielded the dual flip angles minimizing T 1 $$ {T}_1 $$ estimation errors and the adjacent slice offset achieving uniformity in the superimposed slice profile. Phantom experiments demonstrated a strong correlation between the proposed and reference method, and no dependence of the free-running T 1 $$ {T}_1 $$ estimation on heart rates. Adding through-plane respiratory motion correction significantly improved the in-vivo T 1 $$ {T}_1 $$ mapping sharpness and visual quality. Validated against the conventional breath-hold mapping technique, the motion corrected free-running method achieved comparable T 1 $$ {T}_1 $$ mapping quality and repeatability.
CONCLUSION: Respiratory motion is effectively suppressed in the proposed 2D free-running method, which achieves superior T 1 $$ {T}_1 $$ mapping with acceptable repeatability in a short scan time of 46 s.
METHODS: A free-running golden angle radial sequence consisting of T 1 $$ {T}_1 $$ encoding and self-navigated auto motion calibration (SNAC) was developed. The T 1 $$ {T}_1 $$ encoding adopted inversion recovery (IR) prepared interleaved multi-slice acquisition with optimized inter-slice gap to ensure a uniform excitation of the middle slice regardless of through-plane respiratory motion. The flip angles were alternated between the odd and even IR readouts to correct flip-angle errors. SNAC was designed to calibrate the through-plane motion with the respiratory self-navigation signal extracted from the free-running sequence, and integrate the multi-slice data into a through-plane motion-corrected 2D slice for T 1 $$ {T}_1 $$ mapping reconstruction. Numerical simulations were performed to optimize the key sequence parameters, followed by phantom and in-vivo imaging to validate the accuracy and repeatability.
RESULTS: Numerical simulations yielded the dual flip angles minimizing T 1 $$ {T}_1 $$ estimation errors and the adjacent slice offset achieving uniformity in the superimposed slice profile. Phantom experiments demonstrated a strong correlation between the proposed and reference method, and no dependence of the free-running T 1 $$ {T}_1 $$ estimation on heart rates. Adding through-plane respiratory motion correction significantly improved the in-vivo T 1 $$ {T}_1 $$ mapping sharpness and visual quality. Validated against the conventional breath-hold mapping technique, the motion corrected free-running method achieved comparable T 1 $$ {T}_1 $$ mapping quality and repeatability.
CONCLUSION: Respiratory motion is effectively suppressed in the proposed 2D free-running method, which achieves superior T 1 $$ {T}_1 $$ mapping with acceptable repeatability in a short scan time of 46 s.