Cell host & microbe · 2015
Evolution and Spread of Ebola Virus in Liberia, 2014-2015.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Ladner Jason T, Wiley Michael R, Mate Suzanne, Dudas Gytis, Prieto Karla, Lovett Sean, Nagle Elyse R, Beitzel Brett, Gilbert Merle L, Fakoli Lawrence, Diclaro Joseph W, Schoepp Randal J, Fair Joseph, Kuhn Jens H, Hensley Lisa E, Park Daniel J, Sabeti Pardis C, Rambaut Andrew, Sanchez-Lockhart Mariano, Bolay Fatorma K, Kugelman Jeffrey R, Palacios Gustavo
Аннотация
The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.