Biochemical and biophysical research communications · 2025
Gut-pancreas axis in the control of insulin secretion in streptozotocin-resistant rats.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Nomura Kazuhiro, Yamasaki Yuki, Takeji Kana, Deha Sachie, Yamashita Kaho, Izumi-Mishima Yuna, Yasui-Yamada Sonoko, Kuroda Masashi, Harada Nagakatsu, Kitamura Tadahiro, Tsutsumi Yasuo M, Tsutsumi Rie, Nakaya Yutaka, Sakaue Hiroshi
Аннотация
The Spontaneously Running Tokushima Shikoku (SPORTS) rat is characterized by hyperactive behavior but is also a potential model for studies of the role of the gut-pancreas axis in the regulation of insulin secretion. We here explored the role of ghrelin, a hormone associated with appetite regulation, in insulin dynamics within the context of streptozotocin (STZ) resistance in SPORTS rats. Comprehensive analyses-including histological examinations, gene expression profiling, and assessment of metabolic parameters-revealed that SPORTS rats are resistant to STZ-induced pancreatic injury and that, in addition to low circulating ghrelin levels, they manifest increased circulating levels of active glucagon-like peptide-1 (GLP-1) and upregulated expression of Pdx1 in the pancreas. Ghrelin administration attenuated the STZ resistance of these rats, with suppression of GLP-1 and downregulation of Pdx1 expression being implicated in this effect. Our results highlight the complex interplay among ghrelin, GLP-1, and insulin dynamics, and they suggest potential new therapeutic targets for diabetes.