Sports medicine and health science · 2024
Plasma cardiovascular stress biomarkers response to marathon running.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Siekierzycka Anna, Radulska Adrianna, Woźniak Marcin, Pelikant-Małecka Iwona, Janaszak-Jasiecka Anna, Lewicka Ewa, Kalinowski Leszek, Olek Robert A
Аннотация
BACKGROUND: Habitual physical activity is known to support cardiovascular health. However, when intensive exercise is performed for long durations, it can negatively affect the cardiovascular system. We evaluated the exercise-induced physiological responses of cardiac markers in male marathon runners based on basal plasma trimethylamine-N-oxide (TMAO) levels, a metabolite related to major adverse cardiovascular events.
METHODS: Blood samples from 28 marathon runners were collected two weeks before the marathon run (baseline), after finishing the race (post-marathon), and two weeks after the race (2 weeks post-marathon). Serum cardiac troponin I (cTnI), endothelin-1 (ET-1), galectin-3, pentraxin-3, human growth differentiation factor 15, and neopterin were determined by the enzyme immunoassay method. Plasma trimethylamine (TMA) and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method.
RESULTS: Running a marathon increased levels of circulating biomarkers. A greater post-marathon elevation of cTnI and ET-1 was associated with baseline plasma TMAO levels (R = 0.400, p = 0.035 and R = 0.476, p = 0.012, respectively). Moreover, we observed an increase in post-marathon TMA levels.
CONCLUSION: Greater post-marathon elevation of cTnI and ET-1 was associated with higher baseline plasma TMAO levels. Therefore, TMAO could potentially serve as a new marker in assessing the response of cardiovascular stress biomarkers to marathon running.
METHODS: Blood samples from 28 marathon runners were collected two weeks before the marathon run (baseline), after finishing the race (post-marathon), and two weeks after the race (2 weeks post-marathon). Serum cardiac troponin I (cTnI), endothelin-1 (ET-1), galectin-3, pentraxin-3, human growth differentiation factor 15, and neopterin were determined by the enzyme immunoassay method. Plasma trimethylamine (TMA) and TMAO were measured by the ultra-high-performance liquid chromatography-mass spectrometry method.
RESULTS: Running a marathon increased levels of circulating biomarkers. A greater post-marathon elevation of cTnI and ET-1 was associated with baseline plasma TMAO levels (R = 0.400, p = 0.035 and R = 0.476, p = 0.012, respectively). Moreover, we observed an increase in post-marathon TMA levels.
CONCLUSION: Greater post-marathon elevation of cTnI and ET-1 was associated with higher baseline plasma TMAO levels. Therefore, TMAO could potentially serve as a new marker in assessing the response of cardiovascular stress biomarkers to marathon running.