Science advances · 2021
Immune checkpoint inhibitors increase T cell immunity during SARS-CoV-2 infection.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Yatim Nader, Boussier Jeremy, Tetu Pauline, Smith Nikaïa, Bruel Timothée, Charbit Bruno, Barnabei Laura, Corneau Aurélien, Da Meda Laetitia, Allayous Clara, Baroudjian Barouyr, Jebali Majdi, Herms Florian, Grzelak Ludivine, Staropoli Isabelle, Calmettes Vincent, Hadjadj Jerome, Peyrony Olivier, Cassius Charles, LeGoff Jerome, Kramkimel Nora, Aractingi Selim, Fontes Magnus, Blanc Catherine, Rieux-Laucat Frederic, Schwartz Olivier, Terrier Benjamin, Duffy Darragh, Lebbé Celeste
Аннотация
The COVID-19 pandemic has spread worldwide, yet the role of antiviral T cell immunity during infection and the contribution of immune checkpoints remain unclear. By prospectively following a cohort of 292 patients with melanoma, half of which treated with immune checkpoint inhibitors (ICIs), we identified 15 patients with acute or convalescent COVID-19 and investigated their transcriptomic, proteomic, and cellular profiles. We found that ICI treatment was not associated with severe COVID-19 and did not alter the induction of inflammatory and type I interferon responses. In-depth phenotyping demonstrated expansion of CD8 effector memory T cells, enhanced T cell activation, and impaired plasmablast induction in ICI-treated COVID-19 patients. The evaluation of specific adaptive immunity in convalescent patients showed higher spike (S), nucleoprotein (N), and membrane (M) antigen-specific T cell responses and similar induction of spike-specific antibody responses. Our findings provide evidence that ICI during COVID-19 enhanced T cell immunity without exacerbating inflammation.