The journal of medical investigation : JMI · 2003
Long-term follow-up of gastric metaplasia after eradication of Helicobacter pylori.
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Urakami Yoshihito, Sano Toshiaki
Аннотация
BACKGROUNDS AND AIMS: There is no commonly accepted view concerning changes in gastric metaplasia after the eradication of Helicobacter pylori. The aim of this study was to evaluate the long-term course of gastric metaplasia after the eradication of this bacterium.
METHODS: The subjects were 59 patients with duodenal ulcer who were positive for Helicobacter pylori. Forty patients were classified as the eradication group. Gastric metaplasia was endoscopically and histologically evaluated before and after eradication of this bacterium. The follow-up period was 2-7.1 years. In the other 19 patients in the non-eradication group, gastric metaplasia was evaluated before and after treatment of the ulcer. Gastric metaplasia was evaluated in terms of its extent and type in all patients.
RESULTS: Gastric metaplasia showed the incomplete type before eradication but changed to the complete type after eradication, which persisted for a long period. The extent of gastric metaplasia increased after eradication. In the non-eradication group, gastric metaplasia infrequently changed to the complete type during the scarring period of ulcer.
CONCLUSION: Gastric metaplasia changed to the complete type after the eradication of Helicobacter pylori, which persisted for a long period.
METHODS: The subjects were 59 patients with duodenal ulcer who were positive for Helicobacter pylori. Forty patients were classified as the eradication group. Gastric metaplasia was endoscopically and histologically evaluated before and after eradication of this bacterium. The follow-up period was 2-7.1 years. In the other 19 patients in the non-eradication group, gastric metaplasia was evaluated before and after treatment of the ulcer. Gastric metaplasia was evaluated in terms of its extent and type in all patients.
RESULTS: Gastric metaplasia showed the incomplete type before eradication but changed to the complete type after eradication, which persisted for a long period. The extent of gastric metaplasia increased after eradication. In the non-eradication group, gastric metaplasia infrequently changed to the complete type during the scarring period of ulcer.
CONCLUSION: Gastric metaplasia changed to the complete type after the eradication of Helicobacter pylori, which persisted for a long period.
Предметные рубрики MeSH
2-PyridinylmethylsulfinylbenzimidazolesAdultAgedAmoxicillinCicatrixConvalescenceDrug Therapy, CombinationDuodenal UlcerDuodenoscopyFemaleFollow-Up StudiesGastric AcidGastric MucosaGastritisGastroscopyHelicobacter InfectionsHelicobacter pyloriHistamine H2 AntagonistsHumansLansoprazoleMaleMetaplasiaMetronidazoleMiddle AgedMucusOmeprazoleSeverity of Illness Index