Residential exposure to transportation noise and risk of incident atrial fibrillation: a pooled study of 11 prospective Nordic cohorts.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Thacher Jesse D, Roswall Nina, Ögren Mikael, Pyko Andrei, Åkesson Agneta, Oudin Anna, Rosengren Annika, Poulsen Aslak H, Eriksson Charlotta, Segersson David, Rizzuto Debora, Helte Emilie, Andersson Eva M, Aasvang Gunn Marit, Engström Gunnar, Gudjonsdottir Hrafnhildur, Selander Jenny, Christensen Jesper H, Brandt Jørgen, Leander Karin, Overvad Kim, Mattisson Kristoffer, Eneroth Kristina, Stucki Lara, Barregard Lars, Stockfelt Leo, Albin Maria, Simonsen Mette K, Raaschou-Nielsen Ole, Jousilahti Pekka, Tiittanen Pekka, Ljungman Petter L S, Jensen Steen S, Gustafsson Susanna, Yli-Tuomi Tarja, Cole-Hunter Thomas, Lanki Timo, Lim Youn-Hee, Andersen Zorana J, Pershagen Göran, Sørensen Mette
Аннотация
METHODS: We pooled data from 11 Nordic cohorts, totaling 161,115 participants. Based on address history from five years before baseline until end of follow-up, road, railway, and aircraft noise was estimated at a residential level. Incident AF was ascertained via linkage to nationwide patient registries. Cox proportional hazards models were utilized to estimate associations between running 5-year time-weighted mean transportation noise (Lden) and AF after adjusting for sociodemographics, lifestyle, and air pollution.
FINDINGS: We identified 18,939 incident AF cases over a median follow-up of 19.6 years. Road traffic noise was associated with AF, with a hazard ratio (HR) and 95% confidence interval (CI) of 1.02 (1.00-1.04) per 10-dB of 5-year mean time-weighted exposure, which changed to 1.03 (1.01-1.06) when implementing a 53-dB cut-off. In effect modification analyses, the association for road traffic noise and AF appeared strongest in women and overweight and obese participants. Compared to exposures ≤40 dB, aircraft noise of 40.1-50 and > 50 dB were associated with HRs of 1.04 (0.93-1.16) and 1.12 (0.98-1.27), respectively. Railway noise was not associated with AF. We found a HR of 1.19 (1.02-1.40) among people exposed to noise from road (≥45 dB), railway (>40 dB), and aircraft (>40 dB) combined.
INTERPRETATION: Road traffic noise, and possibly aircraft noise, may be associated with elevated risk of AF.
FUNDING: NordForsk.