Distinct smell and taste disorder phenotype of post-acute COVID-19 sequelae.
Обработка статьи · этапы, ошибки и управление
Ошибки и ограничения
История · было → стало
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Rass Verena, Tymoszuk Piotr, Sahanic Sabina, Heim Beatrice, Ausserhofer Dietmar, Lindner Anna, Kofler Mario, Mahlknecht Philipp, Boehm Anna, Hüfner Katharina, Pizzini Alex, Sonnweber Thomas, Kurz Katharina, Pfeifer Bernhard, Kiechl Stefan, Peball Marina, Kindl Philipp, Putnina Lauma, Fava Elena, Djamshidian Atbin, Huber Andreas, Wiedermann Christian J, Sperner-Unterweger Barbara, Wöll Ewald, Beer Ronny, Schiefecker Alois Josef, Bellmann-Weiler Rosa, Bachler Herbert, Tancevski Ivan, Pfausler Bettina, Piccoliori Giuliano, Seppi Klaus, Weiss Günter, Löffler-Ragg Judith, Helbok Raimund
Аннотация
METHODS: OD prevalence was assessed in an ambulatory COVID-19 survey (n = 906, ≥ 90 days follow-up) and an observational cohort of ambulatory and hospitalized individuals (n = 108, 360 days follow-up). Co-occurrence of OD with other symptoms and effects on quality of life, physical and mental health were analyzed by multi-dimensional scaling, association rule mining and semi-supervised clustering.
RESULTS: Both in the ambulatory COVID-19 survey study (72%) and the observational ambulatory and hospitalized cohort (41%) self-reported OD was frequent during acute COVID-19. Recovery from self-reported OD was slow (survey: median 28 days, observational cohort: 90 days). By clustering of the survey data, we identified a predominantly young, female, comorbidity-free group of convalescents with persistent OD and taste disorders (median recovery: 90 days) but low frequency of post-acute fatigue, respiratory or neurocognitive symptoms. This smell and taste disorder cluster was characterized by a high rating of physical performance, mental health, and quality of life as compared with convalescents affected by prolonged fatigue or neurocognitive complaints.
CONCLUSION: Our results underline the heterogeneity of post-acute COVID-19 sequelae calling for tailored management strategies. The persistent smell and taste disorder phenotype is characterized by good clinical, physical, and mental recovery and may pose a minor challenge for public health.
STUDY REGISTRATION: ClinicalTrials.gov: NCT04661462 (survey study), NCT04416100 (observational cohort).