eLife · 2015
Ebola virus disease in the Democratic Republic of the Congo, 1976-2014.
Историческая статьяСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Rosello Alicia, Mossoko Mathias, Flasche Stefan, Van Hoek Albert Jan, Mbala Placide, Camacho Anton, Funk Sebastian, Kucharski Adam, Ilunga Benoit Kebela, Edmunds W John, Piot Peter, Baguelin Marc, Tamfum Jean-Jacques Muyembe
Аннотация
The Democratic Republic of the Congo has experienced the most outbreaks of Ebola virus disease since the virus' discovery in 1976. This article provides for the first time a description and a line list for all outbreaks in this country, comprising 996 cases. Compared to patients over 15 years old, the odds of dying were significantly lower in patients aged 5 to 15 and higher in children under five (with 100% mortality in those under 2 years old). The odds of dying increased by 11% per day that a patient was not hospitalised. Outbreaks with an initially high reproduction number, R (>3), were rapidly brought under control, whilst outbreaks with a lower initial R caused longer and generally larger outbreaks. These findings can inform the choice of target age groups for interventions and highlight the importance of both reducing the delay between symptom onset and hospitalisation and rapid national and international response.