Reproductive biomedicine online · 2025
Chronic air pollution exposure is associated with lower chance of live birth after frozen embryo transfer.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Crouzat Améline, Cremoni Marion, Boukaïdi Samir, Seitz-Polski Barbara, Gauci Pierre-Alexis
Аннотация
RESEARCH QUESTION: To evaluate the effect of 1 year's exposure to ambient air pollution on live birth and ovarian response in women undergoing frozen embryo transfer (FET), using the European air quality limit values in 2030 (LV2030).
DESIGN: Retrospective monocentric study of 255 patients who underwent FET in 2023. Data were leveraged from a prospectively collected clinical cohort, combined with prospective air pollution measurements. Primary outcome was live birth; secondary outcome was the number of oocytes retrieved. Individual exposures to fine particulate matter smaller than 2.5 μm (PM2.5), smaller than 10μm (PM10), nitrogen dioxide (NO2), ozone (O3) and two multi-pollutant indices (CSA, ICAIR) were estimated via high-resolution spatial modelling. Multivariable logistics and linear regression models were used, adjusting for key confounders.
RESULTS: Exposure to air pollution during the year preceding embryo transfer was associated with a lower odds of live birth success up to 77% and 66% for pollutant levels exceeded LV2030 respectively for PM2.5 (OR 0.23, 95% CI 0.06 to 0.79, P = 0.020) and NO2 (OR 0.34, 95% CI 0.12 to 0.98, P = 0.046) and for continuous concentrations for PM10 (OR 0.86, 95% CI 0.74 to 0.99, P = 0.044), NO2 (OR 0.95, 95% CI 0.90 to 0.99, P = 0.028) and CSA (OR 0.78, 95% CI 0.62 to 0.99, P = 0.049). Exposure during the pre-retrieval period showed no significant association with live birth. PM10 exposure in that period was consistently linked to fewer oocytes retrieved (β = -2.61, P = 0.010 for LV2030; β = -0.44, P = 0.007 for continuous exposure).
CONCLUSION: Chronic exposure to air pollutants in the year preceding FET was independently associated with lower odds of live birth success. These results highlight that compliance with European limit values may contribute to improved reproductive outcomes.
DESIGN: Retrospective monocentric study of 255 patients who underwent FET in 2023. Data were leveraged from a prospectively collected clinical cohort, combined with prospective air pollution measurements. Primary outcome was live birth; secondary outcome was the number of oocytes retrieved. Individual exposures to fine particulate matter smaller than 2.5 μm (PM2.5), smaller than 10μm (PM10), nitrogen dioxide (NO2), ozone (O3) and two multi-pollutant indices (CSA, ICAIR) were estimated via high-resolution spatial modelling. Multivariable logistics and linear regression models were used, adjusting for key confounders.
RESULTS: Exposure to air pollution during the year preceding embryo transfer was associated with a lower odds of live birth success up to 77% and 66% for pollutant levels exceeded LV2030 respectively for PM2.5 (OR 0.23, 95% CI 0.06 to 0.79, P = 0.020) and NO2 (OR 0.34, 95% CI 0.12 to 0.98, P = 0.046) and for continuous concentrations for PM10 (OR 0.86, 95% CI 0.74 to 0.99, P = 0.044), NO2 (OR 0.95, 95% CI 0.90 to 0.99, P = 0.028) and CSA (OR 0.78, 95% CI 0.62 to 0.99, P = 0.049). Exposure during the pre-retrieval period showed no significant association with live birth. PM10 exposure in that period was consistently linked to fewer oocytes retrieved (β = -2.61, P = 0.010 for LV2030; β = -0.44, P = 0.007 for continuous exposure).
CONCLUSION: Chronic exposure to air pollutants in the year preceding FET was independently associated with lower odds of live birth success. These results highlight that compliance with European limit values may contribute to improved reproductive outcomes.