Ambient temperature exposure on inflammatory blood proteins-A longitudinal self-sampling survey in young Swedish adults.

The mechanisms by which temperature exposure affects health outcomes remain unclear. In this study, we conducted three repeated measurements (2020-2022) by collecting self-sampled volumetric dry blood spots (DBSs) from 807 participants from the Swedish BAMSE cohort (mean age 25.9 years). By estimating individual-address level daily temperature using a high-resolution spatiotemporal model, we found that 58 (16%) of the 365 studied inflammation-related proteins were significantly associated with short-term exposure to ambient temperatures. The impact of temperature exposure was modified by sex, smoking, asthma, and concurrent exposure to air pollution. The temperature-associated proteins were linked to lung function, blood pressure, and HbA1c with validations in the UK Biobank. Furthermore, peak temperature exposure (both cold and heat) was associated with significantly increased proteomic age acceleration. Our findings suggest that ambient temperature exposure may cause adverse health effects through perturbating inflammation-related proteins.