Rebuilding Public Trust: Factors Influencing Dengue Vaccine Uptake in the Aftermath of the Dengvaxia Controversy in the Philippines: A Partial Least Structural Equation Modeling Approach.

This study examines the factors influencing Dengue vaccine adoption in the Philippines, utilizing an integrated framework based on the Social Cognitive Theory (SCT) and the Trust-Confidence-Cooperation Framework (TCCF). Data were collected from 2863 respondents and analyzed using Partial Least Squares Structural Equation Modeling (PLS-SEM) to explore the relationships between key constructs such as government trust, self-efficacy, observational learning, confidence in vaccines, accessibility, cooperation, and outcome expectations. Ethical clearance was obtained for the study to ensure compliance with research ethics guidelines. The findings reveal that government trust, self-efficacy, observational learning, and accessibility significantly enhance cooperation and vaccine uptake, highlighting their critical roles in shaping vaccination behaviors. However, confidence in vaccines and social influence showed limited direct effects on outcome expectations and self-efficacy, suggesting the need for targeted strategies to bridge these gaps. The study emphasizes the importance of transparent government communication, leveraging trusted role models, and improving accessibility to increase vaccine adoption. While the study offers valuable insights, it acknowledges limitations in sample diversity and the exclusion of certain mediating factors, such as cultural and socio-economic variables. These findings contribute to the theoretical understanding of vaccine adoption and provide practical recommendations for designing effective public health interventions to address vaccine hesitancy and improve adoption rates.