Journal of global health · 2020
Exposure to air pollution and cognitive impairment risk: a meta-analysis of longitudinal cohort studies with dose-response analysis.
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Yu Xiaohui, Zheng Liwen, Jiang Wenjie, Zhang Dongfeng
Аннотация
BACKGROUND: We conducted a meta-analysis to explore the relationship between exposure to air pollution and the risk of cognitive impairment of longitudinal cohort studies.
METHODS: PubMed, Web of Science and Wan Fang databases were searched for relevant articles of longitudinal cohort studies published between January 1950 and September 2019. The pooled relative ratio (RR) and 95% confidence interval (CI) were calculated using the random effect model.
RESULTS: Ten articles involving 519 247 cases among 12 523 553 participants were included in this meta-analysis. The pooled RR of cognitive impairment per 5 μg/m3 increments in exposure to particulate matter ≤2.5 μm (PM2.5) was 1.08 (95% CI = 1.03, 1.13; I2 = 82.2%; Pheterogeneity <0.001). No association was found between nitrogen dioxide/nitrogen oxide (NO2/NOx) and ozone (O3) and cognitive impairment. For PM2.5 exposure, in subgroup analysis, the above-mentioned significant positive association was found among studies conducted in population (RR p er 5 μg/m 3 = 1.05; 95% CI = 1.01,1.09; I2 = 57.4%; Pheterogeneity = 0.016), in North America (RR per 5 μg/m 3 = 1.13; 95% CI = 1.01,1.26; I2 = 86.7%; Pheterogeneity <0.001) and with follow-up duration >10 years (RR p er 5 μg/m 3 = 1.10; 95% CI = 1.03,1.17; I2 = 86.3%; Pheterogeneity <0.001).
CONCLUSIONS: This meta-analysis suggests that exposure to PM2.5 might increase the risk of cognitive impairment.
METHODS: PubMed, Web of Science and Wan Fang databases were searched for relevant articles of longitudinal cohort studies published between January 1950 and September 2019. The pooled relative ratio (RR) and 95% confidence interval (CI) were calculated using the random effect model.
RESULTS: Ten articles involving 519 247 cases among 12 523 553 participants were included in this meta-analysis. The pooled RR of cognitive impairment per 5 μg/m3 increments in exposure to particulate matter ≤2.5 μm (PM2.5) was 1.08 (95% CI = 1.03, 1.13; I2 = 82.2%; Pheterogeneity <0.001). No association was found between nitrogen dioxide/nitrogen oxide (NO2/NOx) and ozone (O3) and cognitive impairment. For PM2.5 exposure, in subgroup analysis, the above-mentioned significant positive association was found among studies conducted in population (RR p er 5 μg/m 3 = 1.05; 95% CI = 1.01,1.09; I2 = 57.4%; Pheterogeneity = 0.016), in North America (RR per 5 μg/m 3 = 1.13; 95% CI = 1.01,1.26; I2 = 86.7%; Pheterogeneity <0.001) and with follow-up duration >10 years (RR p er 5 μg/m 3 = 1.10; 95% CI = 1.03,1.17; I2 = 86.3%; Pheterogeneity <0.001).
CONCLUSIONS: This meta-analysis suggests that exposure to PM2.5 might increase the risk of cognitive impairment.