Air pollution and nonmalignant respiratory mortality in 16 cohorts within the ESCAPE project.
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Dimakopoulou Konstantina, Samoli Evangelia, Beelen Rob, Stafoggia Massimo, Andersen Zorana Jovanovic, Hoffmann Barbara, Fischer Paul, Nieuwenhuijsen Mark, Vineis Paolo, Xun Wei, Hoek Gerard, Raaschou-Nielsen Ole, Oudin Anna, Forsberg Bertil, Modig Lars, Jousilahti Pekka, Lanki Timo, Turunen Anu, Oftedal Bente, Nafstad Per, Schwarze Per E, Penell Johanna, Fratiglioni Laura, Andersson Niklas, Pedersen Nancy, Korek Michal, De Faire Ulf, Eriksen Kirsten Thorup, Tjønneland Anne, Becker Thomas, Wang Meng, Bueno-de-Mesquita Bas, Tsai Ming-Yi, Eeftens Marloes, Peeters Petra H, Meliefste Kees, Marcon Alessandro, Krämer Ursula, Kuhlbusch Thomas A J, Vossoughi Mohammad, Key Timothy, de Hoogh Kees, Hampel Regina, Peters Annette, Heinrich Joachim, Weinmayr Gudrun, Concin Hans, Nagel Gabriele, Ineichen Alex, Jacquemin Bénédicte, Stempfelet Morgane, Vilier Alice, Ricceri Fulvio, Sacerdote Carlotta, Pedeli Xanthi, Katsoulis Michalis, Trichopoulou Antonia, Brunekreef Bert, Katsouyanni Klea
Аннотация
OBJECTIVES: We have investigated the relationship of long-term exposure to air pollution and nonmalignant respiratory mortality in 16 cohorts with individual level data within the multicenter European Study of Cohorts for Air Pollution Effects (ESCAPE).
METHODS: Data from 16 ongoing cohort studies from Europe were used. The total number of subjects was 307,553. There were 1,559 respiratory deaths during follow-up.
MEASUREMENTS AND MAIN RESULTS: Air pollution exposure was estimated by land use regression models at the baseline residential addresses of study participants and traffic-proximity variables were derived from geographical databases following a standardized procedure within the ESCAPE study. Cohort-specific hazard ratios obtained by Cox proportional hazard models from standardized individual cohort analyses were combined using metaanalyses. We found no significant associations between air pollution exposure and nonmalignant respiratory mortality. Most hazard ratios were slightly below unity, with the exception of the traffic-proximity indicators.
CONCLUSIONS: In this study of 16 cohorts, there was no association between air pollution exposure and nonmalignant respiratory mortality.