[Effect of low-dose ionizing radiation on platelet and leukocytes of radiation workers].

Objective

To explore the effect of low-dose ionizing radiation on the platelets and leukocytes of the radiation workers.

Methods

We collected data from a total number of 2 055 radiation related workers and with their cumulative doses. Data on platelets and leukocytes was gathered from physical examination of the staff members, from 2013 to 2015 in Chengdu. T test, variance analysis, χ2 test, linear correlation, covariance analysis and multivariate logistic regression analysis were used to analyze the data.

Results

Results from the covariance analysis showed that with the increase of cumulative doses, the quantity of platelet and leukocyte appeared a decreasing trend. Multivariate logistic regression analysis showed that, with the increase of BMI levels and the medium cumulative dose and above (>4.333 mSv), the risk of thrombocytopenia became more obvious (trend test as P<0.05). In the group with high-dose exposure radiation (>15.639 mSv) and combined factor as smoking, the risk of developing thrombocytopenia would increase (OR=2.33, 95% CI: 1.23-4.44). Staff with cumulative dose of less than 4.332 mSv and exercised more than 1 time per week, the risk of developing low leukocyte would decrease (OR=0.26, 95% CI: 0.09-0.70).

Conclusions

Along with the increase of cumulative doses on exposure to radiation related workers. The quantity of platelet and leukocyte showed a decreasing trend among them. When this high-dose exposure radiation combined with overweight/obesity or cigarette smoking, the risk of developing thrombocytopenia was high. However, physical exercise might have served as protective factor on leukopenia.