[Serum TNFalpha and its receptors in professionals after prolonged exposure to radiation in remote period].

The goal of this study was the detection of serum TNFalpha concentration and soluble receptors (sTNFRI and sTNFRII) in PA Mayak professionals in long-term after the prolonged radiation exposure, subject to cumulative dose. TNFalpha, sTNFRI, and sTNFRII concentration were investigated by ELISA in serum of 59 professionals. Cumulative external doses were within 0.21-7.72 Gy. 239Pu body burden was less than 1.48 kBk. Direct significant correlation was detected between TNFalpha concentration and external dose (0.21-3.(00) Gy; r = 0.41, p = 0.009, n = 40). Serum sTNFRI concentration rose significantly with increasing of cumulative dose. Significant increase of persons number with deviations of sTNFRI concentration from standards in groups with dose higher 1.00 Gy under comparison with control was discovered. The correlation was detected between external dose and serum sTNFRI concentration in long-term after radiation exposure (r = 0.36, p < 0.005). Significant positive correlation was detected between sTNFRI, and sTNFRII under increasing of cumulative external dose (r = 0.60, p = 0.0000004).