Epigenomics · 2016
Tobacco smoking-associated genome-wide DNA methylation changes in the EPIC study.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Ambatipudi Srikant, Cuenin Cyrille, Hernandez-Vargas Hector, Ghantous Akram, Le Calvez-Kelm Florence, Kaaks Rudolf, Barrdahl Myrto, Boeing Heiner, Aleksandrova Krasimira, Trichopoulou Antonia, Lagiou Pagona, Naska Androniki, Palli Domenico, Krogh Vittorio, Polidoro Silvia, Tumino Rosario, Panico Salvatore, Bueno-de-Mesquita Bas, Peeters Petra Hm, Quirós José Ramón, Navarro Carmen, Ardanaz Eva, Dorronsoro Miren, Key Tim, Vineis Paolo, Murphy Neil, Riboli Elio, Romieu Isabelle, Herceg Zdenko
Аннотация
AIM: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern may represent a stable signature of environmental exposure.
MATERIALS & METHODS: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort.
RESULTS: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation.
CONCLUSION: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.
MATERIALS & METHODS: Here, we examined the potential of DNA methylation changes in 910 prediagnostic peripheral blood samples as a marker of exposure to tobacco smoke in a large multinational cohort.
RESULTS: We identified 748 CpG sites that were differentially methylated between smokers and nonsmokers, among which we identified novel regionally clustered CpGs associated with active smoking. Importantly, we found a marked reversibility of methylation changes after smoking cessation, although specific genes remained differentially methylated up to 22 years after cessation.
CONCLUSION: Our study has comprehensively cataloged the smoking-associated DNA methylation alterations and showed that these alterations are reversible after smoking cessation.