Archives of otolaryngology--head & neck surgery · 2004
Serum cotinine level and incident hearing loss: a case-control study.
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Nondahl David M, Cruickshanks Karen J, Dalton Dayna S, Schubert Carla R, Klein Barbara E K, Klein Ronald, Tweed Ted S
Аннотация
BACKGROUND: A growing body of literature suggests an association between cigarette smoking and hearing loss.
OBJECTIVE: To assess the relation between levels of serum cotinine, a biomarker of exposure to tobacco smoke, and incident hearing loss.
DESIGN: A cross-sectional, incident, case-control study of participants selected from a population-based cohort.
SETTING: Testing was conducted at the Beaver Dam Community Hospital, Beaver Dam, Wis.
PARTICIPANTS: A total of 197 participants with incident hearing loss and 394 control participants, aged 53 to 75 years, selected from the 2800 participants of the 5-year follow-up examination of the population-based Epidemiology of Hearing Loss Study, 1998-2000.
MAIN OUTCOME MEASURE: Incident hearing loss. The incidence of hearing loss was defined as a pure-tone average of thresholds at 500, 1000, 2000, and 4000 Hz greater than 25-dB hearing level in either ear at follow-up among those without hearing loss at baseline.
RESULTS: No significant associations were found between serum cotinine levels and incident hearing loss.
CONCLUSIONS: These results were not consistent with a previous report, which found cross-sectional associations between prevalent hearing loss and current smoking and environmental tobacco smoke exposure in the home. Longer-term longitudinal studies of smoking and/or serum cotinine levels and the subsequent development of hearing loss may help clarify these associations.
OBJECTIVE: To assess the relation between levels of serum cotinine, a biomarker of exposure to tobacco smoke, and incident hearing loss.
DESIGN: A cross-sectional, incident, case-control study of participants selected from a population-based cohort.
SETTING: Testing was conducted at the Beaver Dam Community Hospital, Beaver Dam, Wis.
PARTICIPANTS: A total of 197 participants with incident hearing loss and 394 control participants, aged 53 to 75 years, selected from the 2800 participants of the 5-year follow-up examination of the population-based Epidemiology of Hearing Loss Study, 1998-2000.
MAIN OUTCOME MEASURE: Incident hearing loss. The incidence of hearing loss was defined as a pure-tone average of thresholds at 500, 1000, 2000, and 4000 Hz greater than 25-dB hearing level in either ear at follow-up among those without hearing loss at baseline.
RESULTS: No significant associations were found between serum cotinine levels and incident hearing loss.
CONCLUSIONS: These results were not consistent with a previous report, which found cross-sectional associations between prevalent hearing loss and current smoking and environmental tobacco smoke exposure in the home. Longer-term longitudinal studies of smoking and/or serum cotinine levels and the subsequent development of hearing loss may help clarify these associations.