High Rates of Bacteremia and Fluoroquinolone Resistance During an Outbreak of Shigellosis Among People Experiencing Homelessness and Opioid Use Disorder in Philadelphia, Pennsylvania.

In 2023, Philadelphia reported an outbreak of Shigella flexneri infections. We evaluated all patients hospitalized in our health system with shigellosis during this outbreak. Sixty-seven patients were hospitalized, and 21 (31.3%) were bacteremic. Trimethoprim-sulfamethoxazole was the only antibiotic with reliable susceptibility. Most patients had housing insecurity and opioid use disorder.