Chronic obstructive pulmonary diseases (Miami, Fla.) · 2026
Protective Effects of Serum Carotenoid Status on Respiratory Health Among Low-Income Individuals With COPD.
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Jackson Mariah K, Woo Han, Putcha Nirupama, Belz Daniel, Lauver Molly, Lorizio Wendy, Koehler Kirsten, Fawzy Ashraf, Hanson Corri K, Hansel Nadia N
Аннотация
BACKGROUND: Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory disease where diet-derived carotenoids may counteract inflammation and improve COPD outcomes. Our objective was to evaluate associations between serum carotenoid levels and COPD outcomes.
METHODS: Low-income individuals with COPD in the Baltimore, Maryland area completed longitudinal assessment including a panel of 10 serum carotenoids, inflammatory and oxidative stress markers, and COPD outcomes. A total carotenoid level was created by summing the individual value for each carotenoid. Adjusted regression analyses were performed to analyze the association between total and individual carotenoids and COPD outcomes.
RESULTS: Of 98 participants, two-thirds had a household income less than $30,000. In adjusted analyses, each standard deviation increase of total and individual carotenoid levels was significantly associated with better COPD-related health scores and associated with lower frequency of severe exacerbations. Total carotenoid levels had an inverse relationship with tumor necrosis factor alpha: -3.0% (-5.1, -0.8), and interleukin-6: -9.5% (-16.0, -2.5).
CONCLUSION: Higher serum carotenoid levels had a positive impact on COPD health status scores and inflammatory markers, and may lower the incidence of exacerbations. Future research should continue to investigate the role of nutrition as a complementary therapy for lung health.
METHODS: Low-income individuals with COPD in the Baltimore, Maryland area completed longitudinal assessment including a panel of 10 serum carotenoids, inflammatory and oxidative stress markers, and COPD outcomes. A total carotenoid level was created by summing the individual value for each carotenoid. Adjusted regression analyses were performed to analyze the association between total and individual carotenoids and COPD outcomes.
RESULTS: Of 98 participants, two-thirds had a household income less than $30,000. In adjusted analyses, each standard deviation increase of total and individual carotenoid levels was significantly associated with better COPD-related health scores and associated with lower frequency of severe exacerbations. Total carotenoid levels had an inverse relationship with tumor necrosis factor alpha: -3.0% (-5.1, -0.8), and interleukin-6: -9.5% (-16.0, -2.5).
CONCLUSION: Higher serum carotenoid levels had a positive impact on COPD health status scores and inflammatory markers, and may lower the incidence of exacerbations. Future research should continue to investigate the role of nutrition as a complementary therapy for lung health.