American journal of perinatology · 2026
Life Course Perspectives of Adverse Pregnancy Outcomes in Kersa, Eastern Ethiopia: Accelerated Cohort Design.
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Tadele Afework, Dheresa Merga, Abera Muluemebet
Аннотация
OBJECTIVE: Adverse pregnancy outcomes (APOs) are major drivers of maternal and child mortality, especially in low-income countries like Ethiopia. Studies examining such inequities from a life course lens are lacking. Hence, this study investigates generational disparities in the risk of APOs.
STUDY DESIGN: An accelerated cohort design was utilized, recruiting 7,286 women from three birth cohorts (1970s, 1980s, and 1990s) in Kersa, Eastern Ethiopia. A generalized linear mixed-effects model using STATA version 17.0 was used.
RESULTS: Pregnancy outcomes varied across generations. Stillbirths were highest in earlier life course (13.8%) and lowest in later (7.3%). Preterm births declined slightly (9.5% to 8.1%), but risks were greater in later life course. Miscarriages were lowest in Cohort 2 (2.9%). Poor maternal nutrition (MUAC <21 cm; AOR = 2.87 for preterm birth, AOR = 1.71 for stillbirth) and high gravidity (AOR = 2.26 for preterm birth, AOR = 1.51 for stillbirth) were strongly associated with adverse pregnancy outcomes, while lack of maternal education (AOR = 1.45) also increased risk of preterm birth. In contrast, later age at first birth (AOR = 0.43 for preterm birth) and higher household wealth (medium AOR = 0.73; highest AOR = 0.63 for preterm birth) were protective factors. These findings underscore the importance of maternal nutrition, reproductive history, and socioeconomic conditions in determining pregnancy outcomes.
CONCLUSION: Generational disparities highlight the need for multilevel strategies addressing social determinants and maternal care. Future studies to elucidate the biological pathways, such as epigenetic changes, linking early-life exposures to pregnancy outcomes are recommended.
KEY POINTS: · Adverse pregnancy outcomes were observed.. · Study used an accelerated cohort design. · Findings were interpreted through life course perspectives..
STUDY DESIGN: An accelerated cohort design was utilized, recruiting 7,286 women from three birth cohorts (1970s, 1980s, and 1990s) in Kersa, Eastern Ethiopia. A generalized linear mixed-effects model using STATA version 17.0 was used.
RESULTS: Pregnancy outcomes varied across generations. Stillbirths were highest in earlier life course (13.8%) and lowest in later (7.3%). Preterm births declined slightly (9.5% to 8.1%), but risks were greater in later life course. Miscarriages were lowest in Cohort 2 (2.9%). Poor maternal nutrition (MUAC <21 cm; AOR = 2.87 for preterm birth, AOR = 1.71 for stillbirth) and high gravidity (AOR = 2.26 for preterm birth, AOR = 1.51 for stillbirth) were strongly associated with adverse pregnancy outcomes, while lack of maternal education (AOR = 1.45) also increased risk of preterm birth. In contrast, later age at first birth (AOR = 0.43 for preterm birth) and higher household wealth (medium AOR = 0.73; highest AOR = 0.63 for preterm birth) were protective factors. These findings underscore the importance of maternal nutrition, reproductive history, and socioeconomic conditions in determining pregnancy outcomes.
CONCLUSION: Generational disparities highlight the need for multilevel strategies addressing social determinants and maternal care. Future studies to elucidate the biological pathways, such as epigenetic changes, linking early-life exposures to pregnancy outcomes are recommended.
KEY POINTS: · Adverse pregnancy outcomes were observed.. · Study used an accelerated cohort design. · Findings were interpreted through life course perspectives..