Journal of medical virology · 2025

One-Year Quality of Life Among Survivors of Hospitalization for Omicron Infection in Brazil: A Multicentre Prospective Cohort Study.

СтатьяМногоцентровое исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди

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Trott Geraldine, Rover Marciane Maria, Scolari Fernando Luis, da Silva Mariana Motta Dias, de Souza Denise, Dos Santos Rosa da Rosa Minho, De Carli Raíne Fogliati, Roldão Emelyn de Souza, Rech Gabriela Soares, Mocellin Duane, de Souza Jennifer Menna Barreto, Miozzo Aline Paula, Itaqui Carolina Rothmann, da Silva Gabrielle Nunes, da Rosa Decker Sergio Renato, Leite Erica Neves, Ferreira Carlos Delmar do Amaral, da Luz Lucas Gobetti, Rieth Gabriel Beilfuss, Tramujas Lucas, Medrado Fernando Azevedo, Piotto Bruna Fornazieri, Silva Gizelle Fernanda Oliveira, Chaves Josafá Ferreira, Francisco Saionara Cristina, de Menezes Neves Precil Diego Miranda, Sato Victor Augusto Hamamoto, Veiga Viviane Cordeiro, Martins Kaique Lima, de Oliveira Cláudio Dornas, Dos Santos Sabrina Gomes, Fernandes Juliana Cardozo, Lisboa Thiago Costa, Irineu Vivian Menezes, Pompilio Mauricio Antonio, França Adriana de Oliveira, Jaccottet Aline Coletto, Schleder Juliana Carvalho, Nogueira Vinicius Ortigosa, Nobre Vandack, Silveira Daniel Souto, Mesas Cézar Eumann, Miltersteiner Diego, Ortiz Emanuelle Toledo, Blauth Fernando Gioppo, Facchi Luciane Maria, Marcolino Milena Soriano, Antonio Ana Carolina Peçanha, Schvartzman Paulo R, Barreto Bruna Brandão, Robinson Caroline Cabral, Falavigna Maicon, Polanczyk Carisi Anne, Nasi Luiz Antonio, Rosa Regis Goulart, Post‐Covid Brasil 1 Group Autorship

Аннотация

The lingering effects of COVID-19 may impair survivors' long-term health-related quality of life (HRQoL). However, multicentre studies focusing on the Omicron variant, particularly in middle- and low-income settings, are scarce. We conducted a prospective cohort study across 24 Brazilian hospitals between December 2021 and March 2024, when Omicron was the predominant variant. Adult COVID-19 survivors were followed for 12 months via telephone interviews. The primary outcome was HRQoL at 12 months, assessed using the EuroQol five-dimension three-level questionnaire (EQ-5D-3L; range -0.17 to 1.0). All-cause mortality was a secondary outcome. Among 649 participants (47.9% women; median age 71 years), the median EQ-5D-3L utility score at 12 months was 0.69 (IQR 0.41-0.80), and survival was 86.6%. Factors associated with lower HRQoL included female sex, age ≥ 60 years, Charlson comorbidity index ≥ 1, and need for respiratory support. Mortality was associated with age ≥ 60 years (HR 2.81), CCI ≥ 2 (HR 2.17), need for low-flow oxygen therapy (HR 2.03), and BMI ≥ 25 kg/m² (HR 0.58). One year after hospitalization, Omicron survivors in Brazil showed impaired HRQoL and high mortality. Older age, comorbidities, and need for oxygen therapy were linked to worse outcomes. Long-term support strategies are needed for these vulnerable populations.

Предметные рубрики MeSH

Humans Female Male Quality of Life Brazil Aged Prospective Studies Middle Aged COVID-19 Hospitalization SARS-CoV-2 Survivors Adult Surveys and Questionnaires Aged, 80 and over

One-Year Quality of Life Among Survivors of Hospitalization for Omicron Infection in Brazil: A Multicentre Prospective Cohort Study.

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Аннотация

Предметные рубрики MeSH