American journal of surgery · 2025
Intersection of race and poverty for pancreatic adenocarcinoma: A public health crisis.
СтатьяНазвание и аннотация: Перевод в очереди
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Wu Christopher, Holland Michelle, Akinola K Kerrick, McLeod Chandler, Chen Herbert, Rose J Bart, Bhatia Smita, Gillis Andrea
Аннотация
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is aggressive with a poor prognosis, and racial disparities persist despite care advances. The impact of socioeconomic status on mediating these disparities, remain unclear.
METHODS: We used the SEER-17 database to create a cohort of PDAC patients diagnosed between 2005 and 2019. We examined the association between race and all-cause mortality along with a race-stratified Kaplan-Meier analysis on low-income (<$40K) and high-income (>$75K) subgroups.
RESULTS: The cohort included 118,514 patients. Black patients experienced worse survival compared to White patients (HR:1.10, 95 %CI:1.08-1.13, p < 0.001). Three-year survival rate was 9.8 % (95 %CI: 9.4-10.1) for White patients in high-income areas, compared to 8.7 % (95 %CI: 7.8-9.8) for Black patients (p < 0.01). White patients in low-income areas had a survival rate of 6.3 % (95 %CI: 5.4-7.4), compared to Black patients: 5.0 % (95 %CI: 3.5-7.0) (p < 0.01).
CONCLUSIONS: Our study shows significantly poorer survival rates for Black individuals, even with high socioeconomic status, compared to White counterparts, highlighting persistent racial disparities in PDAC outcomes.
METHODS: We used the SEER-17 database to create a cohort of PDAC patients diagnosed between 2005 and 2019. We examined the association between race and all-cause mortality along with a race-stratified Kaplan-Meier analysis on low-income (<$40K) and high-income (>$75K) subgroups.
RESULTS: The cohort included 118,514 patients. Black patients experienced worse survival compared to White patients (HR:1.10, 95 %CI:1.08-1.13, p < 0.001). Three-year survival rate was 9.8 % (95 %CI: 9.4-10.1) for White patients in high-income areas, compared to 8.7 % (95 %CI: 7.8-9.8) for Black patients (p < 0.01). White patients in low-income areas had a survival rate of 6.3 % (95 %CI: 5.4-7.4), compared to Black patients: 5.0 % (95 %CI: 3.5-7.0) (p < 0.01).
CONCLUSIONS: Our study shows significantly poorer survival rates for Black individuals, even with high socioeconomic status, compared to White counterparts, highlighting persistent racial disparities in PDAC outcomes.