Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
Seroprevalence of Helicobacter pylori Infection Among Asymptomatic Patients Served by a Safety-Net Healthcare System.
СтатьяНазвание и аннотация: Перевод в очереди
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Thrift Aaron P, Dinarvand Peyman, Juarez Luis, Brown Jourdan, Avila Daniel, Zafiro Garcia-Villanueva Jennifer Mistica, Danek Lisa C, Mahmood Hammad, Porter Thomas, Gotschall Ann, Pirzada Noreen F, Rueda Jaime J, Lu Lee B, Ali Afroze, Anyakorah Ijeoma, Bhattarai Sanjana J, Fatima Anees, Garcia Jessica, Nguyen Hung V, Joshi Bharat, Juneja Malvika, Lateef Misba S, Mujtaba Najda, Nambi Preethi V, Orr Jay S, Rahman Huma, Nguyen Stephanie, Waqar Amna, Chen Yanyan, Graham David Y, El-Serag Hashem B, Tan Mimi C
Аннотация
BACKGROUND & AIMS: Helicobacter pylori screening and eradication is a cost-effective strategy for primary gastric cancer prevention in high-risk populations outside the United States. There is a paucity of population-based H pylori seroprevalence data available in high-risk U.S. groups, particularly data for low-income, uninsured patient populations.
METHODS: We used data from a cross-sectional study of a largely underserved, immigrant, and minority patient population. Inclusion criteria included asymptomatic individuals 30-65 years of age without prior H pylori testing or treatment. Consented patients completed a study survey and a blood draw to screen for H pylori using IgG serology. We calculated seroprevalence overall and within subgroups of the study population.
RESULTS: Screening for H pylori infection was completed in 1021 individuals. Participants had a mean age of 47.5 years and were 69.9% female, and 88.7% were Hispanic individuals. Overall, 63.9% (95% confidence interval [CI], 60.9%-66.8%) of participants were seropositive for H pylori. H pylori seroprevalence was similar across age groups but was higher among males (69.1%; 95% CI, 63.9%-74.2%) than females (61.6%; 95% CI, 58.1%-65.2%). Seroprevalence of H pylori was highest for Hispanic (65.9%; 95% CI, 62.8%-69.0%) and lowest for non-Hispanic White (45.0%; 95% CI, 23.2%-66.8%) individuals. H pylori seroprevalence was highest among individuals born in Central America (75.1%). Risk for infection was no different between second- and third-generation immigrants.
CONCLUSIONS: In this population-based study, almost two-thirds of asymptomatic patients were seropositive for H pylori. Prevalence was over 40% among all subgroups. Screening solely based on race and ethnicity may inadvertently exacerbate disparities by overlooking confounding factors for infection like low socioeconomic status and regional exposures.
METHODS: We used data from a cross-sectional study of a largely underserved, immigrant, and minority patient population. Inclusion criteria included asymptomatic individuals 30-65 years of age without prior H pylori testing or treatment. Consented patients completed a study survey and a blood draw to screen for H pylori using IgG serology. We calculated seroprevalence overall and within subgroups of the study population.
RESULTS: Screening for H pylori infection was completed in 1021 individuals. Participants had a mean age of 47.5 years and were 69.9% female, and 88.7% were Hispanic individuals. Overall, 63.9% (95% confidence interval [CI], 60.9%-66.8%) of participants were seropositive for H pylori. H pylori seroprevalence was similar across age groups but was higher among males (69.1%; 95% CI, 63.9%-74.2%) than females (61.6%; 95% CI, 58.1%-65.2%). Seroprevalence of H pylori was highest for Hispanic (65.9%; 95% CI, 62.8%-69.0%) and lowest for non-Hispanic White (45.0%; 95% CI, 23.2%-66.8%) individuals. H pylori seroprevalence was highest among individuals born in Central America (75.1%). Risk for infection was no different between second- and third-generation immigrants.
CONCLUSIONS: In this population-based study, almost two-thirds of asymptomatic patients were seropositive for H pylori. Prevalence was over 40% among all subgroups. Screening solely based on race and ethnicity may inadvertently exacerbate disparities by overlooking confounding factors for infection like low socioeconomic status and regional exposures.