Excretion of mutagens in sweat from humans treated with anti-neoplastic drugs.

Base substitution mutagens were isolated and concentrated from sweat and urine of 7 patients treated with cyclophosphamide and other antineoplastic drugs. These samples were tested in Salmonella typhimurium TA 1535. The perspiration samples were collected under normal physiological conditions for 8 h after medication and urine samples were collected 8 h after medication. The perspiration samples from the patients were significantly more mutagenic than perspiration samples from the 7 control persons. No correlation was found between the mutagenicity of the perspiration samples and the urine samples.