ANZ journal of surgery · 2026
Skin Cancers in Australian Liver Transplant Recipients: Risk Factors and Histology.
СтатьяНазвание и аннотация: Перевод в очереди
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Rajaram Rohan, Premaratne Gehan, Tiplady Charlotte, Lok Evania, Li Angela, Majumdar Avik, Jones Robert, Ng Sally Kiu-Huen
Аннотация
BACKGROUND: Skin cancer is one of the most common comorbidities for liver transplant recipients (LTRs). Carcinogenesis is a multifaceted process: immunosuppression and personal risk factors such as smoking status, UV exposure, past history of skin cancer and family history of skin cancer can all play a significant role in determining the extent of skin cancer development.
OBJECTIVE: To undertake a large-scale retrospective case matched cohort study examining the effect of personal and transplant related risk factors in cutaneous carcinogenesis.
METHODS: A case-control study was performed of 114 LTRs who developed skin cancer who were compared to 288 age, sex, time since transplant and aetiology matched controls (1:2 ratio). Data, including histology, were collected via chart review and phone interviews and analysed using logistic regression to determine odds ratios.
RESULTS: A total sample size of 342 was attained. Harmful risk factors that achieved statistical significance were being of Fitzpatrick skin type 1 or 2 (OR = 6.98, p < 0.01), incurring greater than five blistering sun burns (OR = 3.71, p < 0.01), pre-transplant history of skin cancer (OR = 3.36, p < 0.01), smoking status (OR = 3.30, p < 0.01). Immunosuppression protocols that included mTOR inhibitors (OR = 0.30, p < 0.01) were shown to be protective. Most skin cancers were high risk SCCs (63.11%).
CONCLUSIONS: Personal and transplant related risk factors significantly modify the risk of cutaneous carcinogenesis in LTRs. Risk stratification of the likelihood of skin cancer development post liver transplant can help to structure an individualised surveillance scheme to facilitate early detection and treatment of skin cancers in LTRs.
OBJECTIVE: To undertake a large-scale retrospective case matched cohort study examining the effect of personal and transplant related risk factors in cutaneous carcinogenesis.
METHODS: A case-control study was performed of 114 LTRs who developed skin cancer who were compared to 288 age, sex, time since transplant and aetiology matched controls (1:2 ratio). Data, including histology, were collected via chart review and phone interviews and analysed using logistic regression to determine odds ratios.
RESULTS: A total sample size of 342 was attained. Harmful risk factors that achieved statistical significance were being of Fitzpatrick skin type 1 or 2 (OR = 6.98, p < 0.01), incurring greater than five blistering sun burns (OR = 3.71, p < 0.01), pre-transplant history of skin cancer (OR = 3.36, p < 0.01), smoking status (OR = 3.30, p < 0.01). Immunosuppression protocols that included mTOR inhibitors (OR = 0.30, p < 0.01) were shown to be protective. Most skin cancers were high risk SCCs (63.11%).
CONCLUSIONS: Personal and transplant related risk factors significantly modify the risk of cutaneous carcinogenesis in LTRs. Risk stratification of the likelihood of skin cancer development post liver transplant can help to structure an individualised surveillance scheme to facilitate early detection and treatment of skin cancers in LTRs.