Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2026
No Association of Sex or Racial Factors With Outcomes in Adult Intestine-Only Transplant: A United Network for Organ Sharing Database Analysis.
СтатьяНазвание и аннотация: Перевод в очереди
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Cogua Laura M, Tupper Connor J, Faddoul Giovanni, Li Meng-Hao, Koizumi Naoru, Ortiz Jorge
Аннотация
OBJECTIVES: Adult intestine-only transplant is an uncommon procedure for intestinal failure. We assessed demographic factors associated with recipient mortality and graft failure rates in adult intestine-only transplant recipients.
MATERIALS AND METHODS: Data for cases of adult intestine-only transplants diagnosed for the period 2004-2024 were collected from the United Network for Organ Sharing database. Demographic characteristics of recipients, mortality, and graft survival were evaluated among racial groups.
RESULTS: A total of 896 transplants were included. Most were White (75.2%) and were female (56.3%). There were no differences in graft failure or recipient mortality by race/ethnicity or sex. Race/ethnicity was not associated with graft survival for adult intestine-only transplant. Recipient mortality was greater with older recipients (hazard ratio = 1.022; P = .007). Basiliximab/daclizumab was associated with a higher mortality rate (hazard ratio = 1.001; P < .001). There were no racial disparities and no differences in regimens for induction immunosuppression or maintenance immunosuppression with regard to recipient mortality or graft failure.
CONCLUSIONS: Recipient age and basiliximab/daclizumab may significantly influence adult intestine-only transplant recipient survival but not graft outcomes.
MATERIALS AND METHODS: Data for cases of adult intestine-only transplants diagnosed for the period 2004-2024 were collected from the United Network for Organ Sharing database. Demographic characteristics of recipients, mortality, and graft survival were evaluated among racial groups.
RESULTS: A total of 896 transplants were included. Most were White (75.2%) and were female (56.3%). There were no differences in graft failure or recipient mortality by race/ethnicity or sex. Race/ethnicity was not associated with graft survival for adult intestine-only transplant. Recipient mortality was greater with older recipients (hazard ratio = 1.022; P = .007). Basiliximab/daclizumab was associated with a higher mortality rate (hazard ratio = 1.001; P < .001). There were no racial disparities and no differences in regimens for induction immunosuppression or maintenance immunosuppression with regard to recipient mortality or graft failure.
CONCLUSIONS: Recipient age and basiliximab/daclizumab may significantly influence adult intestine-only transplant recipient survival but not graft outcomes.