Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025
Heavy metals and cardiovascular health: Uncovering links and health challenges.
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Ozarde Yogita, Purandare Dishank, Deshmukh Shreya, Gadhave Ranjit
Аннотация
BACKGROUND: Heavy metals, including lead, mercury, cadmium, and arsenic, along with emerging contaminants, pose significant threats to cardiovascular health. These metals are linked to oxidative stress, endothelial dysfunction, inflammation, and epigenetic alterations, contributing to various cardiovascular diseases.
AIM: This review synthesizes current research on the pathways by which heavy metal exposure affects cardiovascular health, highlighting epidemiological trends, vulnerable populations, and potential preventive strategies.
METHODS: A comprehensive review of molecular mechanisms, epidemiological studies, and public health data was conducted to elucidate the links between heavy metal exposure and cardiovascular health.
RESULTS: Mechanisms of Toxicity: Heavy metals induce oxidative stress and inflammation, impair endothelial function, and disrupt calcium signaling. These effects culminate in hypertension, atherosclerosis, myocardial dysfunction, and other cardiovascular pathologies. Epidemiological Trends: Evidence links even low-level exposures to increased Cardio Vascular Disease risk. Regional trends show elevated risks in areas with significant industrial activity or contaminated water supplies. Vulnerable Populations: Children, the elderly, and individuals in low-income or industrially polluted regions exhibit heightened susceptibility. Preventive Strategies: Regulatory actions, improved water safety, dietary interventions, and community awareness are critical in mitigating exposure and its health impacts.
CONCLUSIONS: Environmental exposure to heavy metals significantly elevates cardiovascular disease risk, particularly among vulnerable groups. Urgent public health measures and further research are needed to address the cumulative and synergistic effects of these toxicants.
AIM: This review synthesizes current research on the pathways by which heavy metal exposure affects cardiovascular health, highlighting epidemiological trends, vulnerable populations, and potential preventive strategies.
METHODS: A comprehensive review of molecular mechanisms, epidemiological studies, and public health data was conducted to elucidate the links between heavy metal exposure and cardiovascular health.
RESULTS: Mechanisms of Toxicity: Heavy metals induce oxidative stress and inflammation, impair endothelial function, and disrupt calcium signaling. These effects culminate in hypertension, atherosclerosis, myocardial dysfunction, and other cardiovascular pathologies. Epidemiological Trends: Evidence links even low-level exposures to increased Cardio Vascular Disease risk. Regional trends show elevated risks in areas with significant industrial activity or contaminated water supplies. Vulnerable Populations: Children, the elderly, and individuals in low-income or industrially polluted regions exhibit heightened susceptibility. Preventive Strategies: Regulatory actions, improved water safety, dietary interventions, and community awareness are critical in mitigating exposure and its health impacts.
CONCLUSIONS: Environmental exposure to heavy metals significantly elevates cardiovascular disease risk, particularly among vulnerable groups. Urgent public health measures and further research are needed to address the cumulative and synergistic effects of these toxicants.