The impact of sleep disturbance on post-transplant recovery and quality of life: Neural mechanisms and translational management strategies.

Sleep disturbance is prevalent among solid organ transplant recipients and significantly impairs posttransplant recovery and health-related quality of life (HRQOL). Transplant recipients often experience challenges related to inadequate sleep quality, daytime drowsiness, difficulty falling or staying asleep, as well as various sleep disorders like sleep apnea, narcolepsy, and restless legs syndrome, which are commonly observed in this population. The review paper offers a detailed and wide-ranging examination of the influence that sleep disruption exerts on the recuperation process and overall well-being of individuals following a transplant procedure. It covers the prevalence of sleep disturbance in different types of transplant recipients, the factors contributing to sleep disturbance, the impact of sleep disturbance on the recovery process and quality of life following transplantation, along with interventions which aim at enhancing sleep quality in transplant recipients, which are explored in the study. This is an integrative review linking immunosuppressive drug effects on specific neural circuits, neurotransmitter systems, and inflammatory pathways to post-transplant sleep disturbance. The discussed highlights offer perspectives for healthcare practitioners and researchers engaged in transplantation medicine and neural systems biology research.