Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2025
Clinical Outcomes of Living Donor Kidney Transplant in Older Recipients: A Retrospective Single-Center Analysis.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
El Hennawy Hany M, Azeem Saad Muzaffar, Safar Omar, Al Faifi Abdullah S, Al Atta Eisa, El Madawie Mahmoud Z, El Gamal Galal A, Azeem Sadia, Tawhari Ibrahim, Shalkamy Osama
Аннотация
OBJECTIVES: We evaluated living donor kidney transplant outcomes in older recipients (≥65 years) at Armed Forces Hospitals in the Southern Region from September 2017 to January 2025 and compared results versus younger recipients (<65 years).
MATERIALS AND METHODS: This was a retrospective analysis of 68 older patients (group A) and 316 younger patients (group B) who received tacrolimus, mycophenolate mofetil, and prednisone, with basiliximab induction in 94.1% of group A and 92% of group B. Retransplant occurred in 5.9% of group A and 7.9% of group B.
RESULTS: Older recipients had longer dialysis durations versus younger recipients (4 vs 2 years; P < .001), longer surgeries (230 vs 180 minutes; P < .001), and longer hospital stays (7.5 vs 6.2 days; P < .001), higher rates of delayed graft function (8.8% vs 0.6%; P < .001), and lower immediate graft function (91.1% vs 97.7%; P = .006). At 1 year in group A and group B, graft survival rates (95.5% vs 97.1%; P = .501) and patient survival rates (95.5% vs 98.1%; P = .545) were similar. However, by 3 years, graft survival was lower in group A (86.7%) versus group B (92%) as was patient survival (85.2% vs 93.6%; P < .001). Graft loss within 3 years occurred in 4.4% of older versus 1.89% of younger recipients, and death with a functioning graft was more common in group A (7.3%) than in group B (2.2%). Group A also had higher rates of complications than group B (infections: 13.2% vs 6.3%; surgical site infections: 5.9% vs 0.6%).
CONCLUSIONS: Despite higher risks, group A demon-strated 1-year graft and patient survival rates that were comparable with group B, highlighting feasibility of kidney transplant in well-selected older adults. However, nonadherence was associated with higher infection rates but did not significantly affect long-term outcomes.
MATERIALS AND METHODS: This was a retrospective analysis of 68 older patients (group A) and 316 younger patients (group B) who received tacrolimus, mycophenolate mofetil, and prednisone, with basiliximab induction in 94.1% of group A and 92% of group B. Retransplant occurred in 5.9% of group A and 7.9% of group B.
RESULTS: Older recipients had longer dialysis durations versus younger recipients (4 vs 2 years; P < .001), longer surgeries (230 vs 180 minutes; P < .001), and longer hospital stays (7.5 vs 6.2 days; P < .001), higher rates of delayed graft function (8.8% vs 0.6%; P < .001), and lower immediate graft function (91.1% vs 97.7%; P = .006). At 1 year in group A and group B, graft survival rates (95.5% vs 97.1%; P = .501) and patient survival rates (95.5% vs 98.1%; P = .545) were similar. However, by 3 years, graft survival was lower in group A (86.7%) versus group B (92%) as was patient survival (85.2% vs 93.6%; P < .001). Graft loss within 3 years occurred in 4.4% of older versus 1.89% of younger recipients, and death with a functioning graft was more common in group A (7.3%) than in group B (2.2%). Group A also had higher rates of complications than group B (infections: 13.2% vs 6.3%; surgical site infections: 5.9% vs 0.6%).
CONCLUSIONS: Despite higher risks, group A demon-strated 1-year graft and patient survival rates that were comparable with group B, highlighting feasibility of kidney transplant in well-selected older adults. However, nonadherence was associated with higher infection rates but did not significantly affect long-term outcomes.