Medicine · 2025
Delayed diagnosis of granulomatosis with polyangiitis presenting as irregularly shaped solid lung nodules with heterogeneous enhancement: A case report.
СтатьяКлинический случайНазвание и аннотация: Перевод в очереди
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Mo Ranran, Bian Cuixia, Han Liping
Аннотация
RATIONALE: Granulomatosis with polyangiitis (GPA) is a systemic autoimmune vasculitis. Thoracic radiographic findings in GPA can mimic various pulmonary diseases, potentially leading to misdiagnosis. We describe a case of delayed GPA diagnosis, initially presenting as irregularly shaped solid lung nodules with heterogeneous enhancement, such cases are rarely reported.
PATIENT CONCERNS: A 69-year-old male was initially misdiagnosed with lung cancer based on the identification of solid lung nodules during routine physical examination. Pathological findings from a lung biopsy were inconclusive. Due to the atypical chest computed tomography presentation, the diagnosis was delayed by nearly 2 months and involved 3 different hospitals.
DIAGNOSIS: The definitive clinical diagnosis was GPA complicated by a pulmonary embolism.
INTERVENTIONS: Methylprednisolone was administered, and immunosuppressive therapy was initiated following infection control.
OUTCOMES: At outpatient follow-up, most of the patient's clinical indicators has returned to normal.
LESSONS: Pulmonary involvement occurs in over 90% of GPA cases, with characteristic thoracic radiologic findings including solitary or multiple nodules, masses, cavities, and consolidation, with a propensity for lesion recurrence. Clinicians should consider GPA in antibiotic-refractory "pneumonia" with unexplained extrapulmonary manifestations.
PATIENT CONCERNS: A 69-year-old male was initially misdiagnosed with lung cancer based on the identification of solid lung nodules during routine physical examination. Pathological findings from a lung biopsy were inconclusive. Due to the atypical chest computed tomography presentation, the diagnosis was delayed by nearly 2 months and involved 3 different hospitals.
DIAGNOSIS: The definitive clinical diagnosis was GPA complicated by a pulmonary embolism.
INTERVENTIONS: Methylprednisolone was administered, and immunosuppressive therapy was initiated following infection control.
OUTCOMES: At outpatient follow-up, most of the patient's clinical indicators has returned to normal.
LESSONS: Pulmonary involvement occurs in over 90% of GPA cases, with characteristic thoracic radiologic findings including solitary or multiple nodules, masses, cavities, and consolidation, with a propensity for lesion recurrence. Clinicians should consider GPA in antibiotic-refractory "pneumonia" with unexplained extrapulmonary manifestations.