Nature communications · 2025
No evidence of immune exhaustion after repeated SARS-CoV-2 vaccination in vulnerable and healthy populations.
СтатьяНазвание и аннотация: Перевод в очереди
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Benoit Jenna M, Breznik Jessica A, Wu Ying, Kennedy Allison, Liu Li-Min, Cowbrough Braeden, Baker Barbara, Hagerman Megan, Andary Catherine M, Mushtaha Maha, Abdalla Nora, McNicol Jamie D, Gauvreau Gail, Kim Paul Y, Denburg Judah A, Costa Andrew P, Leong Darryl P, Nazy Ishac, Duong MyLinh, Bramson Jonathan L, Larché Maggie J, Verschoor Chris P, Bowdish Dawn M E
Аннотация
Frequent SARS-CoV-2 vaccination in vulnerable populations has raised concerns that this may contribute to T cell exhaustion, which could negatively affect the quality of immune protection. Herein, we examined the impact of repeated SARS-CoV-2 vaccination on T cell phenotypic and functional exhaustion in frail older adults in long-term care (n = 23), individuals on immunosuppressive drugs (n = 10), and healthy adults (n = 43), in Canada. Spike-specific CD4+ and CD8+ T cell levels did not decline in any cohort following repeated SARS-CoV-2 vaccination, nor did the expression of exhaustion markers on spike-specific or total T cells increase. T cell production of multiple cytokines (i.e. polyfunctionality) in response to the spike protein of SARS-CoV-2 did not decline in any cohort following repeated vaccination. None of the cohorts displayed elevated levels of terminally differentiated T cells following multiple SARS-CoV-2 vaccinations. Thus, repeated SARS-CoV-2 vaccination was not associated with increased T cell exhaustion in older frail adults, immunosuppressed individuals, or healthy adults.