MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1038/s41591-024-03300-3

Медицинская библиотека · Nature medicine · 2024

Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region.

Naveca Felipe Gomes, Almeida Tatiana Amaral Pires de, Souza Victor, Nascimento Valdinete, Silva Dejanane, Nascimento Fernanda, Mejía Matilde, Oliveira Yasmin Silva de, Rocha Luisa, Xavier Natana, Lopes Janis, Maito Rodrigo, Meneses Cátia, Amorim Tatyana, Fé Luciana, Camelo Fernanda Sindeaux, Silva Samyly Coutinho de Aguiar, Melo Alexsandro Xavier de, Fernandes Leíse Gomes, Oliveira Marco Aurélio Almeida de, Arcanjo Ana Ruth, Araújo Guilherme, André Júnior Walter, Carvalho Renata Lia Coragem de, Rodrigues Rosiane, Albuquerque Stella, Mattos Cristiane, Silva Ciciléia, Linhares Aline, Rodrigues Taynã, Mariscal Francy, Morais Márcia Andréa, Presibella Mayra Marinho, Marques Nelson Fernando Quallio, Paiva Anne, Ribeiro Karina, Vieira Deusilene, Queiroz Jackson Alves da Silva, Passos-Silva Ana Maísa, Abdalla Lígia, Santos João Hugo, Figueiredo Regina Maria Pinto de, Cruz Ana Cecília Ribeiro, Casseb Livia Neves, Chiang Jannifer Oliveira, Frutuoso Livia Vinhal, Rossi Agata, Freitas Lucas, Campos Túlio de Lima, Wallau Gabriel Luz, Moreira Emerson, Lins Neto Roberto Dias, Alexander Laura W, Sun Yining, Filippis Ana Maria Bispo de, Gräf Tiago, Arantes Ighor, Bento Ana I, Delatorre Edson, Bello Gonzalo

СтатьяПеревод в очереди

Аннотация

The Brazilian western Amazon is experiencing its largest laboratory-confirmed Oropouche virus (OROV) outbreak, with more than 6,300 reported cases between 2022 and 2024. In this study, we sequenced and analyzed 382 OROV genomes from human samples collected in Amazonas, Acre, Rondônia and Roraima states, between August 2022 and February 2024, to uncover the origin and genetic evolution of OROV in the current outbreak. Genomic analyses revealed that the upsurge of OROV cases in the Brazilian Amazon coincides with spread of a novel reassortant lineage containing the M segment of viruses detected in the eastern Amazon region (2009-2018) and the L and S segments of viruses detected in Peru, Colombia and Ecuador (2008-2021). The novel reassortant likely emerged in the Amazonas state between 2010 and 2014 and spread through long-range dispersion events during the second half of the 2010s. Phylodynamics reconstructions showed that the current OROV spread was driven mainly by short-range (< 2 km) movements consistent with the flight range of vectors. Nevertheless, a substantial proportion (22%) of long-range (>10 km) OROV migrations were also detected, consistent with viral dispersion by humans. Our data provide a view of the unprecedented spread and evolution of OROV in the Brazilian western Amazon region.

Для цитирования: Naveca Felipe Gomes, Almeida Tatiana Amaral Pires de, Souza Victor, Nascimento Valdinete, Silva Dejanane, Nascimento Fernanda, Mejía Matilde, Oliveira Yasmin Silva de, Rocha Luisa, Xavier Natana, Lopes Janis, Maito Rodrigo, Meneses Cátia, Amorim Tatyana, Fé Luciana, Camelo Fernanda Sindeaux, Silva Samyly Coutinho de Aguiar, Melo Alexsandro Xavier de, Fernandes Leíse Gomes, Oliveira Marco Aurélio Almeida de, Arcanjo Ana Ruth, Araújo Guilherme, André Júnior Walter, Carvalho Renata Lia Coragem de, Rodrigues Rosiane, Albuquerque Stella, Mattos Cristiane, Silva Ciciléia, Linhares Aline, Rodrigues Taynã, Mariscal Francy, Morais Márcia Andréa, Presibella Mayra Marinho, Marques Nelson Fernando Quallio, Paiva Anne, Ribeiro Karina, Vieira Deusilene, Queiroz Jackson Alves da Silva, Passos-Silva Ana Maísa, Abdalla Lígia, Santos João Hugo, Figueiredo Regina Maria Pinto de, Cruz Ana Cecília Ribeiro, Casseb Livia Neves, Chiang Jannifer Oliveira, Frutuoso Livia Vinhal, Rossi Agata, Freitas Lucas, Campos Túlio de Lima, Wallau Gabriel Luz, Moreira Emerson, Lins Neto Roberto Dias, Alexander Laura W, Sun Yining, Filippis Ana Maria Bispo de, Gräf Tiago, Arantes Ighor, Bento Ana I, Delatorre Edson, Bello Gonzalo. Human outbreaks of a novel reassortant Oropouche virus in the Brazilian Amazon region.. Nature medicine. 2024. DOI: 10.1038/s41591-024-03300-3.

Предметные рубрики MeSH

BrazilHumansDisease OutbreaksReassortant VirusesOrthobunyavirusPhylogenyGenome, ViralBunyaviridae InfectionsAnimals
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.