Experimental and clinical transplantation : official journal of the Middle East Society for Organ Transplantation · 2024
A Case of Primary Renal Allograft Dysfunction Caused by Missed Monoclonal Disease.
Клинический случайСтатьяНазвание и аннотация: Перевод в очереди
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Toprak Zeki, Ersoy Yesil Ezgi, Zerenler Gursoy Fatima, Keski Hakan, Kayabasi Hasan, Sit Dede, Kucuk Eyup V
Аннотация
We present an unusual etiology of primary renal allograft dysfunction attributed to myeloma cast nephropathy in a patient with no history of multiple myeloma before kidney transplant. The patient, a 54-year-old woman, had been on hemodialysis for 6 months before transplant for presumed diabetic nephropathy; she developed graft dysfunction immediately after transplant. Graft biopsy specimens were consistent with myeloma cast nephropathy, and she was treated with bortezomib, cyclophosphamide, and dexamethasone. She achieved a complete hematological response and regained excellent graft function 3 months after transplant. The patient then received autologous stem cell transplant 8 months after kidney transplant. To our knowledge, this is the second report of a successful graft outcome after chemotherapy and the first report treated with autologous stem cell transplantation after remission of monoclonal disease.