Медицинская библиотека · Pharmacogenomics · 2022

SLCO1B3 T334G polymorphisms and mycophenolate mofetil-related adverse reactions in kidney transplant recipients.

Zhong Jianxun, Yang Kun, Zhang Mi, Wu Jianhua, Liu Liang

СтатьяПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Background

The correlation between SLCO1B3 T334G polymorphisms and mycophenolate mofetil (MMF) adverse reactions in kidney recipients is unknown.

Methods

A single-center, retrospective study was performed in which 111 patients were divided into four groups according to the type of adverse effect experienced. The clinical data and concentrations of MMF at different months after transplantation were statistically analyzed.

Results

The G allele in the gastrointestinal reaction group was significantly higher than that in the no adverse effects group (p < 0.05). Logistic regression model showed that the SLCO1B3 T334G genotype was an independent risk factor for gastrointestinal reactions caused by MMF.

Conclusion

Patients with the SLCO1B3 T334G GG genotype were more likely to experience gastrointestinal reactions.

Для цитирования: Zhong Jianxun, Yang Kun, Zhang Mi, Wu Jianhua, Liu Liang. SLCO1B3 T334G polymorphisms and mycophenolate mofetil-related adverse reactions in kidney transplant recipients.. Pharmacogenomics. 2022. DOI: 10.2217/pgs-2022-0101.

Предметные рубрики MeSH

Humans Mycophenolic Acid Immunosuppressive Agents Kidney Transplantation Retrospective Studies Polymorphism, Genetic Drug-Related Side Effects and Adverse Reactions Graft Rejection Solute Carrier Organic Anion Transporter Family Member 1B3

Подготовка и перевод публикации

Обработка статьи · этапы, ошибки и управление

Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.