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Войти в исследования Dermatologie (Heidelberg, Germany) · 2022
[Melanoma microenvironment-impact of modern therapies].
Аннотация на английскомСтатьяОбзорНазвание и аннотация: Перевод в очереди
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Sirokay Judith, Mauch Cornelia
Аннотация
BACKGROUND: A considerable proportion of patients with advanced melanoma succumb to metastatic disease despite the initial success of modern therapies.
OBJECTIVES: An overview of the melanoma tumor microenvironment with special focus on approved therapies and new innovative strategies is given.
METHODS: Current clinical trials and scientific insights concerning the impact of the tumor microenvironment on progression and therapy of advanced melanoma are reviewed and discussed.
RESULTS: The tumor microenvironment with its manifold components and interactions plays a major role in the treatment of malignant melanoma.
CONCLUSION: Innovative new strategies that target an immunosuppressive microenvironment may improve the therapeutic efficacy of current treatment of advanced melanoma.
OBJECTIVES: An overview of the melanoma tumor microenvironment with special focus on approved therapies and new innovative strategies is given.
METHODS: Current clinical trials and scientific insights concerning the impact of the tumor microenvironment on progression and therapy of advanced melanoma are reviewed and discussed.
RESULTS: The tumor microenvironment with its manifold components and interactions plays a major role in the treatment of malignant melanoma.
CONCLUSION: Innovative new strategies that target an immunosuppressive microenvironment may improve the therapeutic efficacy of current treatment of advanced melanoma.