[Melanoma microenvironment-impact of modern therapies].

BACKGROUND

A considerable proportion of patients with advanced melanoma succumb to metastatic disease despite the initial success of modern therapies.

OBJECTIVES

An overview of the melanoma tumor microenvironment with special focus on approved therapies and new innovative strategies is given.

METHODS

Current clinical trials and scientific insights concerning the impact of the tumor microenvironment on progression and therapy of advanced melanoma are reviewed and discussed.

RESULTS

The tumor microenvironment with its manifold components and interactions plays a major role in the treatment of malignant melanoma.

CONCLUSION

Innovative new strategies that target an immunosuppressive microenvironment may improve the therapeutic efficacy of current treatment of advanced melanoma.