The American journal of tropical medicine and hygiene · 2024
Birth Outcomes Related to Prenatal Zika, Dengue, and Other Flavivirus Infections in the Zika en Embarazadas y Niños Prospective Cohort Study in Colombia.
СтатьяНазвание и аннотация: Перевод в очереди
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Tannis Ayzsa, Newton Suzanne, Rico Angelica, Gonzalez Maritza, Benavides Monica, Ricaldi Jessica N, Rodriguez Helena, Zambrano Laura D, Daza Marcela, Godfred-Cato Shana, Thomas Jennifer D, Acosta Jacqueline, Maniatis Panagiotis, Daniels Jonathan B, Burkel Veronica, Ailes Elizabeth C, Valencia Diana, Gilboa Suzanne M, Jamieson Denise J, Mercado Marcela, Villanueva Julie M, Honein Margaret A, Ospina Martha L, Tong Van T
Аннотация
Zika virus (ZIKV) infection in pregnancy is associated with severe abnormalities of the brain and eye and other adverse outcomes. Zika en Embarazadas y Niños was a prospective cohort study conducted in multiple Colombian cities that enrolled pregnant women in their first trimester. Specimens collected from pregnant women (n = 1,519) during February 2017-September 2018 and their infants (n = 1,080) during June 2017-March 2019 were tested for prenatal ZIKV infection by nucleic acid amplification tests or IgM antibody testing. Zika virus infection in pregnancy was present in 3.2% of pregnant women (incidence rate [IR] per 1,000 person-months = 5.9, 95% CI: 4.3-7.8). Presumptive ZIKV infection was present in 0.8% of infants (IR = 1.6, 95% CI: 0.7-2.9). Five percent of infants with prenatal ZIKV exposure or infection presented with Zika-associated abnormalities; 4.7% were small for gestational age. Understanding the risk of ZIKV infection during pregnancy and associated adverse outcomes can help inform counseling efforts.