Медицинская библиотека · Science (New York, N.Y.) · 2026

Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling.

Karavaeva Iuliia, Basse Astrid Linde, Trammell Samuel A J, Hussain Mohammed Faiz, Markussen Lasse Kruse, Havelund Jesper F, Isidor Marie Sophie, Chatoff Adam, Andress Huacachino Andrea, Richter Hannah J, Birla Meghna, Chubanava Sabina, Deleye Yann, Arianti Rini, Tandio David, Utzon Sarah E, Kaiser Zafir, Shen Yachen, Neess Ditte, Embring Hannes, Menon Dilip, Conway Olivia J, Sass Frederike, Finger Fabian, Argemi-Muntadas Lidia, Ma Tao, Sustarsic Elahu G, Kristensen Cecilie Kynding, McIntyre Rebecca L, Martinez Genesee J, Husted Anna Sofie, Emmett Matthew J, Kipp Zachary A, Frost Mikkel, Jedrychowski Mark P, van Weeghel Michel, Majd Homa, Zhuravleva Ekaterina, McGarrah Robert W, Plucińska Kaja, Midha Mohit K, Prokesch Andreas, Cohen Paul, Granneman James G, Seale Patrick, Houtkooper Riekelt H, Hansen Jacob B, Gygi Steven P, Schwartz Thue W, Gillum Matthew P, Hinds Terry D, Soccio Raymond E, White Phillip J, Kunji Edmund R S, Moritz Thomas, Treebak Jonas T, Kristóf Endre, Mandrup Susanne, Emanuelli Brice, Snyder Nathaniel W, Fazakerley Daniel J, Kazak Lawrence, Færgeman Nils J, Lazar Mitchell A, Gerhart-Hines Zachary

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Аннотация

Adipocyte lipid metabolism is coordinated by circadian rhythms, diet, and environmental temperature, but how these diverse signals are molecularly integrated remains unknown. We showed that these cues converge on the orphan mitochondrial transporter SLC25A34 to orchestrate lipid cycling. During the sleep phase, the adipocyte clock suppresses Slc25a34 expression through the REV-ERB transcriptional repressors. Entering the active phase, consuming lipid-rich diets, or exposure to cold abolishes REV-ERB repression, and lipolytic signals stimulate Slc25a34 transcription through the peroxisome proliferator-activated receptors. SLC25A34 is proposed to import oxaloacetate into mitochondria, dually supporting the tricarboxylic acid cycle and cytosolic acetyl-coenzyme A (acetyl-CoA) production. Elevated cytosolic acetyl-CoA then fuels the synthesis of lipids and promotes the transcription of genes enhancing mitochondrial oxidation. Thus, SLC25A34 confers circadian, dietary, and temperature control of adipocyte lipid metabolism.

Для цитирования: Karavaeva Iuliia, Basse Astrid Linde, Trammell Samuel A J, Hussain Mohammed Faiz, Markussen Lasse Kruse, Havelund Jesper F, Isidor Marie Sophie, Chatoff Adam, Andress Huacachino Andrea, Richter Hannah J, Birla Meghna, Chubanava Sabina, Deleye Yann, Arianti Rini, Tandio David, Utzon Sarah E, Kaiser Zafir, Shen Yachen, Neess Ditte, Embring Hannes, Menon Dilip, Conway Olivia J, Sass Frederike, Finger Fabian, Argemi-Muntadas Lidia, Ma Tao, Sustarsic Elahu G, Kristensen Cecilie Kynding, McIntyre Rebecca L, Martinez Genesee J, Husted Anna Sofie, Emmett Matthew J, Kipp Zachary A, Frost Mikkel, Jedrychowski Mark P, van Weeghel Michel, Majd Homa, Zhuravleva Ekaterina, McGarrah Robert W, Plucińska Kaja, Midha Mohit K, Prokesch Andreas, Cohen Paul, Granneman James G, Seale Patrick, Houtkooper Riekelt H, Hansen Jacob B, Gygi Steven P, Schwartz Thue W, Gillum Matthew P, Hinds Terry D, Soccio Raymond E, White Phillip J, Kunji Edmund R S, Moritz Thomas, Treebak Jonas T, Kristóf Endre, Mandrup Susanne, Emanuelli Brice, Snyder Nathaniel W, Fazakerley Daniel J, Kazak Lawrence, Færgeman Nils J, Lazar Mitchell A, Gerhart-Hines Zachary. Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling.. Science (New York, N.Y.). 2026. DOI: 10.1126/science.adz4797.

Предметные рубрики MeSH

Animals Adipocytes Mitochondria Mice Circadian Rhythm Acetyl Coenzyme A Lipid Metabolism Nuclear Receptor Subfamily 1, Group D, Member 1 Citric Acid Cycle Diet Cold Temperature Transcription, Genetic Lipolysis Mitochondrial Membrane Transport Proteins Dicarboxylic Acid Transporters Mitochondrial Proteins CLOCK Proteins

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