The effect of viscoelasticity of the tissue on the magneto-responsive drug delivery system.

One way to deliver a drug and control its release is to use magnetic nanoparticles as drug carriers and conduct them by a magnetic field. In this method, drugs and magnetic nanoparticles (usually based on iron, nickel, cobalt or their oxides) are designed and prepared in a combination and injected into the bloodstream upstream of the tissue. These nanoparticles move through the bloodstream and approach the magnetic field. In this area, a magnetic field is applied to these nanoparticles in order to be absorbed and cause the accumulation of these carriers and increase their concentration in the vessel wall. A coupled non-Fickian model for targeted drug delivery from vessel wall into the tumor tissue using magnetic nanoparticle is proposed. The model takes into account all effective fields (chemical, mechanical and magnetic) and other contributed fields such as convection due to bloodstream. In this work, the effect of viscoelasticity on the nanoparticles concentration release in the tumor in the presence of a magnetic field is studied. The influence of the parameters on the transport of the nanoparticles concentration from the vessel wall into the tumor tissue is analysed. The stability analysis of the model under the initial perturbations is studied.