MedElevator Войти в исследования
← Поиск публикаций

DOI 10.1289/ehp.1409149

Медицинская библиотека · Environmental health perspectives · 2015

IARC monographs: 40 years of evaluating carcinogenic hazards to humans.

Pearce Neil, Blair Aaron, Vineis Paolo, Ahrens Wolfgang, Andersen Aage, Anto Josep M, Armstrong Bruce K, Baccarelli Andrea A, Beland Frederick A, Berrington Amy, Bertazzi Pier Alberto, Birnbaum Linda S, Brownson Ross C, Bucher John R, Cantor Kenneth P, Cardis Elisabeth, Cherrie John W, Christiani David C, Cocco Pierluigi, Coggon David, Comba Pietro, Demers Paul A, Dement John M, Douwes Jeroen, Eisen Ellen A, Engel Lawrence S, Fenske Richard A, Fleming Lora E, Fletcher Tony, Fontham Elizabeth, Forastiere Francesco, Frentzel-Beyme Rainer, Fritschi Lin, Gerin Michel, Goldberg Marcel, Grandjean Philippe, Grimsrud Tom K, Gustavsson Per, Haines Andy, Hartge Patricia, Hansen Johnni, Hauptmann Michael, Heederik Dick, Hemminki Kari, Hemon Denis, Hertz-Picciotto Irva, Hoppin Jane A, Huff James, Jarvholm Bengt, Kang Daehee, Karagas Margaret R, Kjaerheim Kristina, Kjuus Helge, Kogevinas Manolis, Kriebel David, Kristensen Petter, Kromhout Hans, Laden Francine, Lebailly Pierre, LeMasters Grace, Lubin Jay H, Lynch Charles F, Lynge Elsebeth, 't Mannetje Andrea, McMichael Anthony J, McLaughlin John R, Marrett Loraine, Martuzzi Marco, Merchant James A, Merler Enzo, Merletti Franco, Miller Anthony, Mirer Franklin E, Monson Richard, Nordby Karl-Cristian, Olshan Andrew F, Parent Marie-Elise, Perera Frederica P, Perry Melissa J, Pesatori Angela Cecilia, Pirastu Roberta, Porta Miquel, Pukkala Eero, Rice Carol, Richardson David B, Ritter Leonard, Ritz Beate, Ronckers Cecile M, Rushton Lesley, Rusiecki Jennifer A, Rusyn Ivan, Samet Jonathan M, Sandler Dale P, de Sanjose Silvia, Schernhammer Eva, Costantini Adele Seniori, Seixas Noah, Shy Carl, Siemiatycki Jack, Silverman Debra T, Simonato Lorenzo, Smith Allan H, Smith Martyn T, Spinelli John J, Spitz Margaret R, Stallones Lorann, Stayner Leslie T, Steenland Kyle, Stenzel Mark, Stewart Bernard W, Stewart Patricia A, Symanski Elaine, Terracini Benedetto, Tolbert Paige E, Vainio Harri, Vena John, Vermeulen Roel, Victora Cesar G, Ward Elizabeth M, Weinberg Clarice R, Weisenburger Dennis, Wesseling Catharina, Weiderpass Elisabete, Zahm Shelia Hoar

СтатьяResearch Support, N.I.H., IntramuralПеревод в очереди

Аннотация

BACKGROUND

Recently, the International Agency for Research on Cancer (IARC) Programme for the Evaluation of Carcinogenic Risks to Humans has been criticized for several of its evaluations, and also for the approach used to perform these evaluations. Some critics have claimed that failures of IARC Working Groups to recognize study weaknesses and biases of Working Group members have led to inappropriate classification of a number of agents as carcinogenic to humans.

OBJECTIVES

The authors of this Commentary are scientists from various disciplines relevant to the identification and hazard evaluation of human carcinogens. We examined criticisms of the IARC classification process to determine the validity of these concerns. Here, we present the results of that examination, review the history of IARC evaluations, and describe how the IARC evaluations are performed.

DISCUSSION: We concluded that these recent criticisms are unconvincing. The procedures employed by IARC to assemble Working Groups of scientists from the various disciplines and the techniques followed to review the literature and perform hazard assessment of various agents provide a balanced evaluation and an appropriate indication of the weight of the evidence. Some disagreement by individual scientists to some evaluations is not evidence of process failure. The review process has been modified over time and will undoubtedly be altered in the future to improve the process. Any process can in theory be improved, and we would support continued review and improvement of the IARC processes. This does not mean, however, that the current procedures are flawed.

CONCLUSIONS

The IARC Monographs have made, and continue to make, major contributions to the scientific underpinning for societal actions to improve the public's health.

Для цитирования: Pearce Neil, Blair Aaron, Vineis Paolo, Ahrens Wolfgang, Andersen Aage, Anto Josep M, Armstrong Bruce K, Baccarelli Andrea A, Beland Frederick A, Berrington Amy, Bertazzi Pier Alberto, Birnbaum Linda S, Brownson Ross C, Bucher John R, Cantor Kenneth P, Cardis Elisabeth, Cherrie John W, Christiani David C, Cocco Pierluigi, Coggon David, Comba Pietro, Demers Paul A, Dement John M, Douwes Jeroen, Eisen Ellen A, Engel Lawrence S, Fenske Richard A, Fleming Lora E, Fletcher Tony, Fontham Elizabeth, Forastiere Francesco, Frentzel-Beyme Rainer, Fritschi Lin, Gerin Michel, Goldberg Marcel, Grandjean Philippe, Grimsrud Tom K, Gustavsson Per, Haines Andy, Hartge Patricia, Hansen Johnni, Hauptmann Michael, Heederik Dick, Hemminki Kari, Hemon Denis, Hertz-Picciotto Irva, Hoppin Jane A, Huff James, Jarvholm Bengt, Kang Daehee, Karagas Margaret R, Kjaerheim Kristina, Kjuus Helge, Kogevinas Manolis, Kriebel David, Kristensen Petter, Kromhout Hans, Laden Francine, Lebailly Pierre, LeMasters Grace, Lubin Jay H, Lynch Charles F, Lynge Elsebeth, 't Mannetje Andrea, McMichael Anthony J, McLaughlin John R, Marrett Loraine, Martuzzi Marco, Merchant James A, Merler Enzo, Merletti Franco, Miller Anthony, Mirer Franklin E, Monson Richard, Nordby Karl-Cristian, Olshan Andrew F, Parent Marie-Elise, Perera Frederica P, Perry Melissa J, Pesatori Angela Cecilia, Pirastu Roberta, Porta Miquel, Pukkala Eero, Rice Carol, Richardson David B, Ritter Leonard, Ritz Beate, Ronckers Cecile M, Rushton Lesley, Rusiecki Jennifer A, Rusyn Ivan, Samet Jonathan M, Sandler Dale P, de Sanjose Silvia, Schernhammer Eva, Costantini Adele Seniori, Seixas Noah, Shy Carl, Siemiatycki Jack, Silverman Debra T, Simonato Lorenzo, Smith Allan H, Smith Martyn T, Spinelli John J, Spitz Margaret R, Stallones Lorann, Stayner Leslie T, Steenland Kyle, Stenzel Mark, Stewart Bernard W, Stewart Patricia A, Symanski Elaine, Terracini Benedetto, Tolbert Paige E, Vainio Harri, Vena John, Vermeulen Roel, Victora Cesar G, Ward Elizabeth M, Weinberg Clarice R, Weisenburger Dennis, Wesseling Catharina, Weiderpass Elisabete, Zahm Shelia Hoar. IARC monographs: 40 years of evaluating carcinogenic hazards to humans.. Environmental health perspectives. 2015. DOI: 10.1289/ehp.1409149.

Предметные рубрики MeSH

Biomedical ResearchCarcinogens, EnvironmentalHumansInternational AgenciesNeoplasmsPublic HealthPublications
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.