Theranostics · 2026
Enzyme-responsive hydrogel coating for in situ re-endothelialization of bioprosthetic heart valves.
СтатьяНазвание и аннотация: Перевод в очереди
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Liang Xuyue, Tong Qi, Bei Zhongwu, Luo Tianying, Ye Lin, Pan Meng, Yang Yun, Chu Bingyang, Qian Yongjun, Qian Zhiyong
Аннотация
BACKGROUND: Bioprosthetic heart valves (BHVs) replacement serves as a critical treatment for severe valvular heart disease. However, it often faces irreversible damage caused by thrombosis, inflammation, and calcification, severely limiting its therapeutic value for younger patients.
METHODS: Herein, we construct a biomimetic hydrogel coating loaded with cerium dioxide nanoparticles and vascular endothelial growth factor on the surface of BHVs material. This design aims to suppress material-induced thrombosis and inflammation, modulate the local microenvironment, achieve in situ re-endothelialization, and enhance the therapeutic potential of BHVs.
RESULTS: The findings demonstrate that the hydrogel coating improved the antithrombotic and anti-inflammatory properties of the BHVs material. Furthermore, in vivo implantation in a rat abdominal aorta model exhibited effective in situ re-endothelialization.
CONCLUSION: The hydrogel coating system developed in this study promoted in situ re-endothelialization of BHVs material and holds promise for extending its service lifespan. This work provides a strategy for enhancing the therapeutic potential of BHVs for younger patients.
METHODS: Herein, we construct a biomimetic hydrogel coating loaded with cerium dioxide nanoparticles and vascular endothelial growth factor on the surface of BHVs material. This design aims to suppress material-induced thrombosis and inflammation, modulate the local microenvironment, achieve in situ re-endothelialization, and enhance the therapeutic potential of BHVs.
RESULTS: The findings demonstrate that the hydrogel coating improved the antithrombotic and anti-inflammatory properties of the BHVs material. Furthermore, in vivo implantation in a rat abdominal aorta model exhibited effective in situ re-endothelialization.
CONCLUSION: The hydrogel coating system developed in this study promoted in situ re-endothelialization of BHVs material and holds promise for extending its service lifespan. This work provides a strategy for enhancing the therapeutic potential of BHVs for younger patients.