[Atrial fibrillation: challenge of antithrombotic treatment].

Antithrombotic treatment is a crucial challenge in the management of patients with atrial fibrillation (AF). It is the only treatment which can decrease mortality in relation with AF. It can also prevent the first cause of dependency in elderly: stroke. Vitamin K antagonists are the more potent drugs to reduce the risk of ischemic stroke in patient with AF. Aspirin, unfractioned heparine or low molecular weight heparin and thienopyridine can also play a role in the antithrombotic therapy in special situations.