Thermal, ventilatory, and gluco-regulatory responses during exercise following short-term acetylsalicylic acid ingestion.

Acetylsalicylic acid and exercise combined produce perturbations in thermal, respiratory and carbohydrate metabolism. However, the therapeutic implications of these therapies are antithrombotic and fibrinolytic respectively. In a double-blind, counterbalanced cross-over design of eight men, salicylate ingestion in combination with 60 min of moderate intensity exercise (50% VO2 max) significantly increased respiratory rate and oxygen consumption (p less than 0.05) both at rest and during the exercise protocol. The effect of acetylsalicylic acid ingestion on gluco-regulatory and counter-regulatory hormones was not significant compared to the placebo. These data suggest a safe prophylactic role for a combined short-term acetylsalicylic acid ingestion and exercise therapy in the development of coronary artery disease when exercising in a thermal neutral environment.