Varicella pneumonia associated with incomplete vaccination in a patient with trisomy 21: A case report.

Varicella pneumonia is a rare but severe complication of varicella-zoster infection in adults. We present what is, to our knowledge, the first documented case of a 24-year-old woman with trisomy 21 who developed disseminated varicella and varicella pneumonia, likely exacerbated by the absence of childhood varicella vaccination. Her social background, including single-parent upbringing and childhood relocation, contributed to her incomplete immunization history. This case highlights the convergence of immunological and social vulnerability and underscores the need for comprehensive vaccination assessments in adults with complex medical and social histories to prevent severe infectious diseases.