Journal of magnetic resonance imaging : JMRI · 2026
Association Between Plasma Methylglyoxal and White Matter Hyperintensities in MR in Acute Ischemic Stroke Patients With Small Artery Occlusion.
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Liu Lei, Wei Chenchen, Ma Aijun
Аннотация
BACKGROUND: Cerebral small vessel disease (CSVD) is an important risk factor for stroke and cognitive impairment, adversely affecting long-term outcomes. Methylglyoxal (MGO), a by-product of glycolysis, is implicated in various vascular complications.
PURPOSE: To explore the correlation between MGO and CSVD, particularly with white matter hyperintensities (WMH).
STUDY TYPE: Prospective.
POPULATION: One hundred and fifteen patients with first-ever small artery occlusion (SAO) within 72 h of onset were enrolled, with a mean age of 63.83 ± 10.92 years, of whom 75 (65.2%) were male.
FIELD STRENGTH/SEQUENCE: 1.5T or 3T; fast spin-echo for T1- and T2-weighted imaging, fluid-attenuated inversion recovery (FLAIR), diffusion-weighted imaging (DWI), and susceptibility-weighted imaging (SWI).
ASSESSMENT: Two neurologists independently evaluated the conventional MRI biomarkers of CSVD, including WMH, enlarged perivascular spaces, lacunes (LAC), and cerebral microbleeds; fasting blood samples were collected both within 72 h and between 8 and 14 days after the onset of the disease to measure MGO.
STATISTICAL TESTS: T-test, Wilcoxon Mann-Whitney test, chi-square test, Spearman correlation analysis, ANOVA or the Kruskal-Wallis test; logistic regression analysis, intraclass correlation coefficient (ICC). p < 0.05 was considered statistically significant.
RESULTS: Elevated MGO levels at admission were independently associated with CSVD (odds ratio [OR] 1.007, 95% confidence interval [CI] 1.002-1.011), and the severity of WMH (OR 1.004, 95% CI 1.001-1.008) and deep white matter hyperintensities (D-WMH) (OR 1.004, 95% CI 1.000-1.007). MGO levels also showed a positive correlation with LAC (correlation coefficient [r] = 0.225) but no significant correlation with periventricular white matter hyperintensities (PV-WMH) (r = 0.172, p = 0.066). Furthermore, there was no significant difference in MGO levels between admission and discharge (t = 1.932, p = 0.056). The reproducibility of MRI parameters was excellent (ICC 0.966-0.976).
DATA CONCLUSION: Elevated MGO levels in patients with first-ever SAO were associated with the presence and severity of WMH, particularly D-WMH.
LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY: Stage 1.
PURPOSE: To explore the correlation between MGO and CSVD, particularly with white matter hyperintensities (WMH).
STUDY TYPE: Prospective.
POPULATION: One hundred and fifteen patients with first-ever small artery occlusion (SAO) within 72 h of onset were enrolled, with a mean age of 63.83 ± 10.92 years, of whom 75 (65.2%) were male.
FIELD STRENGTH/SEQUENCE: 1.5T or 3T; fast spin-echo for T1- and T2-weighted imaging, fluid-attenuated inversion recovery (FLAIR), diffusion-weighted imaging (DWI), and susceptibility-weighted imaging (SWI).
ASSESSMENT: Two neurologists independently evaluated the conventional MRI biomarkers of CSVD, including WMH, enlarged perivascular spaces, lacunes (LAC), and cerebral microbleeds; fasting blood samples were collected both within 72 h and between 8 and 14 days after the onset of the disease to measure MGO.
STATISTICAL TESTS: T-test, Wilcoxon Mann-Whitney test, chi-square test, Spearman correlation analysis, ANOVA or the Kruskal-Wallis test; logistic regression analysis, intraclass correlation coefficient (ICC). p < 0.05 was considered statistically significant.
RESULTS: Elevated MGO levels at admission were independently associated with CSVD (odds ratio [OR] 1.007, 95% confidence interval [CI] 1.002-1.011), and the severity of WMH (OR 1.004, 95% CI 1.001-1.008) and deep white matter hyperintensities (D-WMH) (OR 1.004, 95% CI 1.000-1.007). MGO levels also showed a positive correlation with LAC (correlation coefficient [r] = 0.225) but no significant correlation with periventricular white matter hyperintensities (PV-WMH) (r = 0.172, p = 0.066). Furthermore, there was no significant difference in MGO levels between admission and discharge (t = 1.932, p = 0.056). The reproducibility of MRI parameters was excellent (ICC 0.966-0.976).
DATA CONCLUSION: Elevated MGO levels in patients with first-ever SAO were associated with the presence and severity of WMH, particularly D-WMH.
LEVEL OF EVIDENCE: 1 TECHNICAL EFFICACY: Stage 1.