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Nature · 2025

The Taiwan Precision Medicine Initiative provides a cohort for large-scale studies.

СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод в очереди
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Yang Hsin-Chou, Kwok Pui-Yan, Li Ling-Hui, Liu Yi-Min, Jong Yuh-Jyh, Lee Kang-Yun, Wang Da-Wei, Tsai Ming-Fang, Yang Jenn-Hwai, Chen Chien-Hsiun, Yeh Erh-Chan, Wei Chun-Yu, Fann Cathy S-J, Huang Yen-Tsung, Chen Chia-Wei, Lee Yi-Ju, Chu Shih-Kai, Ho Chih-Hsing, Yang Cheng-Shin, Lee Yungling Leo, Chen Hung-Hsin, Hou Ming-Chih, Chiou Jeng-Fong, Yang Shun-Fa, Wang Chih-Hung, Huang Chih-Yang, Chiu Kuan-Ming, Chen Ming, Chiang Fu-Tien, Lee Sing-Lian, Chen Shiou-Sheng, Yao Wei-Jen, Chien Chih-Cheng, Lin Shih-Yao, Chang Fu-Pang, Ho Hsiang-Ling, Yeh Yi-Chen, Tseng Wei-Cheng, Lin Ming-Hwai, Chang Hsiao-Ting, Tseng Ling-Ming, Liang Wen-Yih, Chen Paul Chih-Hsueh, Hang Jen-Fan, Lin Shih-Chieh, Chan Yu-Jiun, Kuo Ying-Ju, Wang Lei-Chi, Pan Chin-Chen, Hsieh Yu-Cheng, Chen Yi-Ming, Hsiao Tzu-Hung, Lin Ching-Heng, Chen Yen-Ju, Chen I-Chieh, Mao Chien-Lin, Chang Shu-Jung, Chang Yen-Lin, Liao Yi-Ju, Lai Chih-Hung, Lee Wei-Ju, Tung Hsin, Yen Ting-Ting, Yen Hsin-Chien, Shih Chun-Ming, Chou Teh-Ying, Liou Tsan-Hon, Chiang Chen-Yuan, Cherng Yih-Giun, Chen Chih-Hwa, Chiu Chao-Hua, Tseng Sung-Hui, Lin Emily Pei-Ying, Chen Ying-Ju, Chuang Hui-Ping, Chen Tsai-Chuan, Huang Wei-Ting, Sin Joey, Liu I-Ling, Chen Yi-Chen, Chao Kuo-Kuang, Wu Yu-Min, Yu Pin-Pin, Chang Lung-Pao, Yen Kuei-Yao, Chang Li-Ching, Sheen Yi-Jing, Chen Yuan-Tsong, Kan Kamhon, Tsai Hsiang-Lin, Wang Yao-Kuang, Hou Ming-Feng, Yang Yuan-Han, Kuo Chao-Hung, Wu Wen-Jeng, Huang Jee-Fu, Chong Inn-Wen, Tsai Jong-Rung, Lin Cheng-Yu, Yu Ming-Chin, Lee Tsong-Hai, Tsai Meng-Han, Ou Yu-Che, Chen Pin-Yuan, Hu Tsung-Hui, Shyu Yu-Chiau, Cheng Chih-Kuang, Fang Yu-Jen, Hsieh Song-Chou, Chen Chien-Hung, Chen Chieh-Chang, Li Ko-Jen, Lin Chin-Hsien, Chiu Hsien-Yi, Wu Chen-Chi, Chen Chun-Yen, Chu Shi-Jye, Liu Feng-Cheng, Yang Fu-Chi, Chang Hsin-An, Chen Wei-Liang, Yang Sung-Sen, Sung Yueh-Feng, Wang Tso-Fu, Lin Shinn-Zong, Wu Yen-Wen, Wu Chien-Sheng, Jiang Ju-Ying, Ma Gwo-Chin, Chang Ting-Yu, Hwang Juey-Jen, Kao Kuo-Jang, Hung Chen-Fang, Chiu Ting-Fang, Chen Po-Yueh, Tsui Kochung, Wu Ming-Shiang, Pang See-Tong, Chen Shih-Ann, Chen Wei-Ming, Chen Chun-Houh, Sheu Wayne Huey-Herng, Wu Jer-Yuarn

Аннотация

Han Chinese people comprise nearly 20% of the global population but remain under-represented in genetic studies1,2, so there is an urgent need for large-scale cohorts to advance precision medicine. Here we present the Taiwan Precision Medicine Initiative (TPMI), established by Academia Sinica in collaboration with 16 major medical centres around Taiwan, which has recruited 565,390 participants who consent to provide DNA samples for genetic profiling and grant access to their electronic medical records (EMRs) for research. EMR access is both retrospective and prospective, allowing longitudinal studies. Genetic profiling is done with population-optimized arrays of single-nucleotide polymorphisms for people of Han Chinese ancestry, which enable genome-wide association3,4, phenome-wide association5,6 and polygenic risk score7,8 studies to be performed to evaluate common disease risk and pharmacogenetic response. Participants also agreed to be re-contacted for future research and receive personalized genetic risk profiles with health management recommendations. The TPMI has established the TPMI Data Access Platform, a central database and analysis platform that both safeguards the security of the data and facilitates academic research. As a large cohort of individuals with non-European ancestry that merges genetic profiles with EMR data and enables longitudinal follow-up, TPMI provides a unique resource that could be used to validate genetic risk prediction models, perform clinical trials of risk-based health management and inform health policies. Ultimately, the TPMI cohort will contribute to global genetic research and serve as a model for population-based precision medicine.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты