Natural product research · 2023
Phytochemical profiling of the essential oils from three Curcuma species and their in vitro and in silico dengue protease inhibition activity.
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Jani Nor Akmalazura, Maarof Noor Inani, Zahari Miew Mohamad Fitri Miew, Jamil Mailina, Zakaria Iffah Izzati, Mohamad Zobir Siti Zuraidah, Kasim Noraini, Salin Nurul Hanim, Mohamad Ali Nor Azah, Khalid Wan Elina Faradilla Wan, Pungot Noor Hidayah
Аннотация
The chemical compositions, in vitro and in silico anti-dengue activity of the essential oils of the rhizomes of Curcuma longa Linn., C. aeruginosa Roxb., and C. xanthorrhiza Roxb. had been investigated. The C. longa oil was mainly composed of ar-turmerone (54.0%) and curlone (17.7%), while the C. aeruginosa oil was rich in curzerenone (23.4%), 1,8-cineole (21.2%), and camphor (7.1%). Xanthorrhizol (21.6%), β-curcumene (19.5%), ar-curcumene (14.2%), and camphor (9.2%) were the major compounds in the C. xanthorrhiza oil. Among the oils, the C. longa oil was found to be the most active NSB-NS3 protease inhibitor (IC50 1.98 μg/mL). PLS biplot disclosed that the essential oils were classified into three separated clusters based on their characteristic chemical compositions, with C. longa positioned closest to the in vitro anti-dengue activity. Four compounds from the C. longa oil have both hydrogen and hydrophobic bonds that could be responsible for the DENV-2 NS2B-NS3 inhibitory effect.