Recent advances in the synthesis of SGLT2 Inhibitors and natural products from carbohydrates.

Gliflozins are an important class of drugs used in the treatment of type 2 diabetes, a serious and prevalent condition in modern times. Sodium-glucose co-transporter 2 (SGLT-2) inhibitors represent a recent advancement in diabetes treatment, effectively lowering blood sugar levels in patients with type 2 diabetes. Many monosaccharides and their derivatives, such as glycals, play a key role as building blocks in the synthesis of glycosides, particularly C-glycosides, which possess unique structural stability and biological significance. These compounds are crucial in the total synthesis of natural drugs, branched sugars, and other biologically active molecules. This review highlights the recent advancement in the synthesis of SGLT-2 inhibitors and natural products synthesized from carbohydrates made between 2010 and 2024.