MedElevator Войти в исследования
← Поиск публикаций

DOI 10.2147/ptt.s535791

Медицинская библиотека · Psoriasis (Auckland, N.Z.) · 2025

Integrated Single-Cell RNA Sequencing and Proteome-Wide Mendelian Randomization Identifies Therapeutic Targets for Psoriasis and Associated Complications.

Korst Charlotte L B M, Tahri Sabrin, Duetz Carolien, Bruins Wassilis S C, de Jonge A Vera, de Jong Madelon E, Fokkema Cathelijne, Smits Febe, Groen Kaz, Verkleij Christie P M, Frerichs Kristine A, Papazian Natalie, van Duin Mark, van Beek Gregory, Hoogenboezem Remco, Baardemans Thomas, Dal Collo Giada, Stoetman Elodie C G, Cosovic Meliha, Twickler Inoka, Rentenaar Rosa, Eken Merve, Homan-Weert Paola M, Saraci Elona, D'Agostino Mattia, van der Velden Vincent H J, Sanders Mathijs A, Gay Francesca, Broijl Annemiek, Moreau Philippe, Sonneveld Pieter, Zweegman Sonja, Mutis Tuna, Cupedo Tom, van de Donk Niels W C J

СтатьяПеревод пока не подготовлен

Аннотация

BACKGROUND

To identify new targets for protein-based treatments in psoriasis and evaluate the possible negative impacts of these druggable proteins.

METHODS

We carried out an extensive analysis of the entire set of proteins in the blood (proteome-wide) to determine if there are causal links between certain blood proteins and the likelihood of developing psoriasis. The proteins were selected from the UK Biobank Pharma Proteomics Project (UKBPPP) database, which includes genetic data for 2,940 different blood proteins. We obtained the cis-expression quantitative trait locus (cis-eQTL) of druggable genes from eQTLGen Consortium as exposure and the genome-wide association study (GWAS) of psoriasis.

RESULTS

Our research discovered a strong genetic link between plasma APOF, ATP6V1G2, IFNLR1, CRELD1, PRSS8, and TNF proteins and a higher chance of having psoriasis. These proteins share genetic variations associated with psoriasis (PPH3+PPH4>0.8). The ROC curves derived from these protein quantity trait loci (pQTLs) demonstrate that they can distinguish between individuals with psoriasis and those without. The druggable gene analysis showed that simvastatin is related to TNF based on the Drug SIGnatures DataBase webtool.

CONCLUSION

Our study has explored the causal relationships between six blood proteins and psoriasis, offering a detailed insight into potential therapeutic targets. Among them, simvastatin might have an effect on psoriasis via TNF.

Для цитирования: Korst Charlotte L B M, Tahri Sabrin, Duetz Carolien, Bruins Wassilis S C, de Jonge A Vera, de Jong Madelon E, Fokkema Cathelijne, Smits Febe, Groen Kaz, Verkleij Christie P M, Frerichs Kristine A, Papazian Natalie, van Duin Mark, van Beek Gregory, Hoogenboezem Remco, Baardemans Thomas, Dal Collo Giada, Stoetman Elodie C G, Cosovic Meliha, Twickler Inoka, Rentenaar Rosa, Eken Merve, Homan-Weert Paola M, Saraci Elona, D'Agostino Mattia, van der Velden Vincent H J, Sanders Mathijs A, Gay Francesca, Broijl Annemiek, Moreau Philippe, Sonneveld Pieter, Zweegman Sonja, Mutis Tuna, Cupedo Tom, van de Donk Niels W C J. Integrated Single-Cell RNA Sequencing and Proteome-Wide Mendelian Randomization Identifies Therapeutic Targets for Psoriasis and Associated Complications.. Psoriasis (Auckland, N.Z.). 2025. DOI: 10.2147/ptt.s535791.
Подготовка и перевод публикации
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

Тип публикации указан по данным источника. Уровень доказательности автоматически не присваивается.